The Lpt ABC transporter for lipopolysaccharide export to the cell surface

被引：20

作者：

Sperandeo, Paola ^{[1
]}

Martorana, Alessandra M. ^{[1
]}

Polissi, Alessandra ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Farmacol & Biomol, Via Balzaretti 9, I-20133 Milan, Italy

来源：

RESEARCH IN MICROBIOLOGY | 2019年 / 170卷 / 08期

关键词：

Outer membrane biogenesis; LPS transport; Lpt machinery; ABC transporter; TRANSENVELOPE PROTEIN COMPLEX; OUTER-MEMBRANE; ESCHERICHIA-COLI; INNER-MEMBRANE; STRUCTURAL BASIS; FUNCTIONAL-CHARACTERIZATION; ENVELOPE BIOGENESIS; LIPID-A; MACHINERY; ATPASE;

D O I：

10.1016/j.resmic.2019.07.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The surface of the outer membrane of Gram-negative bacteria is covered by a tightly packed layer of lipopolysaccharide molecules which provide a barrier against many toxic compounds and antibiotics. Lipopolysaccharide, synthesized in the cytoplasm, is assembled in the periplasmic leaflet of the inner membrane where the intermembrane Lpt system mediates its transport to the cell surface. The first step of lipopolysaccharide transport is its extraction from the outer leaflet of inner membrane powered by the atypical LptB(2)FGC ABC transporter. Here we review latest advances leading to understanding at molecular level how lipopolysaccharide is transported irreversibly to the outer membrane. (C) 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：366 / 373

页数：8

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