Lifestyle factors associated with sex differences in Kaposi sarcoma incidence among adult black South Africans: A case-control study

被引:0
作者
Motlhale, Melitah [1 ,2 ]
Sitas, Freddy [3 ,4 ,5 ]
Bradshaw, Debbie [3 ]
Chen, Wenlong Carl [1 ,6 ]
Singini, Mwiza Gideon [1 ,2 ]
de Villiers, Chantal Babb [7 ]
Lewis, Cathryn M. [8 ,9 ]
Muchengeti, Mazvita [1 ,2 ,10 ]
Waterboer, Tim [11 ]
Mathew, Christopher G. [6 ,7 ,9 ]
Newton, Robert [12 ,13 ]
Singh, Elvira [1 ,2 ,12 ]
机构
[1] Natl Hlth Lab Serv, Natl Canc Registry, Johannesburg, South Africa
[2] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Div Epidemiol & Biostat, Johannesburg, South Africa
[3] South African Med Res Council, Burden Dis Res Unit, Cape Town, South Africa
[4] Univ New South Wales, Ctr Primary Hlth Care & Equ, Sch Populat Hlth, Sydney, NSW, Australia
[5] Univ Sydney, Menzies Ctr Hlth Policy, Sch Publ Hlth, Sydney, NSW, Australia
[6] Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa
[7] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Div Human Genet, Johannesburg, South Africa
[8] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London SE1 9RT, England
[9] Kings Coll London, Fac Life Sci & Med, Dept Med & Mol Genet, London SE1 9RT, England
[10] Stellenbosch Univ, South African DSI NRF Ctr Excellence Epidemiol Mo, Stellenbosch, South Africa
[11] German Canc Res Ctr, Div Infect & Canc Epidemiol, Heidelberg, Germany
[12] MRC UVRI & LSHTM Uganda Res Unit, Entebbe, Uganda
[13] Univ York, York, N Yorkshire, England
基金
英国医学研究理事会;
关键词
Kaposi sarcoma; HIV; Sex ratio; Johannesburg cancer study; South Africa; HUMAN CHORIONIC-GONADOTROPIN; RISK-FACTORS; HUMAN-HERPESVIRUS-8; INFECTION; HERPESVIRUS DNA; POPULATION; EPIDEMIOLOGY; TRANSMISSION; PREVALENCE; WOMEN; KSHV;
D O I
10.1016/j.canep.2022.102158
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Kaposi Sarcoma (KS) is endemic in several countries in Southern and Eastern Africa, relatively rare worldwide but a leading cancer among people living with HIV. KS has always been more common in adult males than females. We assessed the prevalence of known cancer modifying factors (parity, hormonal contraceptive use in females, sex-partners, smoking and alcohol consumption in both sexes), and their relationship to KS, and whether any of these could account for the unequal KS sex ratios. We calculated logistic regression case-control adjusted odds ratios (ORadj), and 95% confidence intervals (95%CI), between KS and each of the modifying factors, using appropriate comparison controls. Controls were cancer types that had no known relationship to exposures of interest (infection or alcohol or smoking or contraceptive use). The majority of the 1275 KS cases were HIV positive (97%), vs. 15.7% in 10,309 controls. The risk of KS among those with HIV was high in males (ORadj=116.70;95%CI=71.35-190.88) and females (ORadj=93.91;95%CI=54.22-162.40). Among controls, the prevalence of smoking and alcohol consumption was five and three times higher in males vs. females. We found a positive association between KS and heavy vs. non-drinking (ORadj=1.31;95%CI=1.03-1.67), and in current heavy vs. never smokers (ORadj=1.82;95%CI=1.07-3.10). These associations remained positive for alcohol consumption (but with wider CIs) after stratification by sex, and restriction to HIV positive participants. We found no evidence of interactions of smoking and alcohol by sex. Smoking and alcohol consumption may provide a possible explanation for the KS sex differences, given both exposures are more common in men, but confounding and bias cannot be fully ruled out. The role smoking and alcohol play in relation to viral loads of HIV/ KSHV, differences in immunological responses or other genetic differences between males and females warrant further studies.
引用
收藏
页数:8
相关论文
共 48 条
  • [1] Seroprevalence of HHV-8, CMV, and EBV among the general population in Ghana, West Africa
    Adjei, Andrew A.
    Armah, Henry B.
    Gbagbo, Foster
    Boamah, Isaac
    Adu-Gyamfi, Clement
    Asare, Isaac
    [J]. BMC INFECTIOUS DISEASES, 2008, 8 (1)
  • [2] Risk Factors for Classical Kaposi Sarcoma on a Population-based Case-control Study in Sicily
    Anderson, Lesley A.
    Lauria, Carmela
    Romano, Nino
    Brown, Elizabeth E.
    Whitby, Denise
    Graubard, Barry I.
    Li, Yan
    Messina, Angelo
    Gafa, Lorenzo
    Vitale, Francesco
    Goedert, James J.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (12) : 3435 - 3443
  • [3] Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis
    Begre, Lorin
    Rohner, Eliane
    Mbulaiteye, Sam M.
    Egger, Matthias
    Bohlius, Julia
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2016, 139 (04) : 776 - 783
  • [4] Chen W.C., 2020, CANCER EPIDEMIOL, P65, DOI DOI 10.1016/J.CANEP.2020.101701
  • [5] HIV-associated malignancies in sub-Saharan Africa: progress, challenges, and opportunities
    Chinula, Lameck
    Moses, Agnes
    Gopal, Satish
    [J]. CURRENT OPINION IN HIV AND AIDS, 2017, 12 (01) : 89 - 95
  • [6] DIFFERENCES IN ANDROGENS OF HIV-POSITIVE PATIENTS WITH AND WITHOUT KAPOSI-SARCOMA
    CHRISTEFF, N
    WINTER, C
    GHARAKHANIAN, S
    THOBIE, N
    WIRBEL, E
    COSTAGLIOLA, D
    NUNEZ, EA
    ROZENBAUM, W
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1995, 48 (06) : 513 - 518
  • [7] The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic
    Cook-Mozaffari, P
    Newton, R
    Beral, V
    Burkitt, DP
    [J]. BRITISH JOURNAL OF CANCER, 1998, 78 (11) : 1521 - 1528
  • [8] Dalla Pria Alessia, 2019, F1000Res, V8, DOI 10.12688/f1000research.17401.1
  • [9] Geographic Variation in the Prevalence of Kaposi Sarcoma-Associated Herpesvirus and Risk Factors for Transmission
    de Sanjose, Silvia
    Mbisa, Georgina
    Perez-Alvarez, Susana
    Benavente, Yolanda
    Sukvirach, Sukhon
    Nguyen Trong Hieu
    Shin, Hai-Rim
    Pham Thi Hoang Anh
    Thomas, Jaiyeola
    Lazcano, Eduardo
    Matos, Elena
    Herrero, Rolando
    Munoz, Nubia
    Molano, Monica
    Franceschi, Silvia
    Whitby, Denise
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (10) : 1449 - 1456
  • [10] Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma
    Dedicoat, M
    Newton, R
    [J]. BRITISH JOURNAL OF CANCER, 2003, 88 (01) : 1 - 3