The Role of Hydrogen Sulfide in Respiratory Diseases

被引：44
作者：
Khattak, Saadullah [1 ,2 ]
Zhang, Qian-Qian [1 ]
Sarfraz, Muhammad [1 ,3 ]
Muhammad, Pir [4 ]
Ngowi, Ebenezeri Erasto [1 ,5 ]
Khan, Nazeer Hussain [1 ,2 ]
Rauf, Saqib [6 ]
Wang, Yi-Zhen [1 ]
Qi, Hui-Wen [1 ]
Wang, Di [1 ]
Afzal, Attia [1 ,3 ]
Ji, Xin-Ying [1 ,7 ]
Wu, Dong-Dong [1 ,8 ]
机构：
[1] Henan Univ, Sch Basic Med Sci, Henan Int Joint Lab Nucl Prot Regulat, Kaifeng 475004, Peoples R China
[2] Henan Univ, Sch Life Sci, Kaifeng 475004, Peoples R China
[3] Univ Lahore, Fac Pharm, Lahore 56400, Pakistan
[4] Henan Univ, Henan Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Peoples R China
[5] Dar Es Salaam Univ Coll Educ, Dept Biol Sci, Fac Sci, Dar Es Salaam 2329, Tanzania
[6] Univ Peshawar, Dept Zool, Islamia Coll, Peshawar, Pakistan
[7] Henan Univ, Sch Basic Med Sci, Kaifeng Key Lab Infect & Biol Safety, Kaifeng 475004, Peoples R China
[8] Henan Univ, Sch Stomatol, Kaifeng 475004, Peoples R China
来源：
BIOMOLECULES | 2021年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
hydrogen sulfide; respiratory diseases; metabolism processes; signaling pathways; ACUTE LUNG INJURY; CYSTATHIONINE-BETA-SYNTHASE; SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE; OXIDATIVE STRESS; H2S BIOSYNTHESIS; MOUSE MODEL; GASTROINTESTINAL SAFE; AIRWAY INFLAMMATION; SODIUM THIOSULFATE;
D O I：
10.3390/biom11050682
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H2S for respiratory diseases has been widely investigated. H2S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H2S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases. Besides, we also summarized H2S production in the lung and its metabolism processes in respiratory diseases.
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页数：25
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