The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS

被引：9

作者：

Tong, Y. ^{[1
]}

Orang'o, E. ^{[2
]}

Nakalembe, M. ^{[3
]}

Tonui, P. ^{[2
]}

Itsura, P. ^{[2
]}

Muthoka, K. ^{[2
]}

Titus, M. ^{[4
]}

Kiptoo, S. ^{[2
]}

Mwangi, A. ^{[2
]}

Ong'echa, J. ^{[5
]}

Tonui, R. ^{[2
]}

Odongo, B. ^{[2
]}

Mpamani, C. ^{[3
]}

Rosen, B. ^{[6
]}

Moormann, A. ^{[7
]}

Cu-Uvin, S. ^{[8
]}

Bailey, J. A. ^{[8
]}

Oduor, C., I ^{[8
]}

Ermel, A. ^{[1
]}

Yiannoutsos, C. ^{[1
]}

Musick, B. ^{[1
]}

Sang, E. ^{[9
]}

Ngeresa, A. ^{[9
]}

Banturaki, G. ^{[3
]}

Kiragga, A. ^{[3
]}

Zhang, J. ^{[10
]}

Song, Y. ^{[10
]}

Chintala, S. ^{[1
]}

Katzenellenbogen, R. ^{[1
]}

Loehrer, P. ^{[1
]}

Brown, D. R. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[2] Moi Univ, Eldoret, Kenya

[3] Makerere Univ, Infect Dis Inst, Kampala, Uganda

[4] Maseno Univ, Kisumu, Kenya

[5] Kenya Govt Med Res Ctr, Eldoret, Kenya

[6] Beaumont Gynecol Oncol, Royal Oak, MI USA

[7] Univ Massachusetts, Chan Med Sch, Worcester, MA 01605 USA

[8] Brown Univ, Providence, RI 02912 USA

[9] AMPATH, Eldoret, Kenya

[10] Indiana Univ, Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA

来源：

ANNALS OF MEDICINE | 2022年 / 54卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HPV; HIV; Kenya; Uganda; cervical cancer; VISUAL INSPECTION; ACETIC-ACID; INFECTED WOMEN; PAP-SMEAR; IMMUNODEFICIENCY; RISK; PERSISTENCE; PREVENTION; CYTOLOGY; POPULATION;

D O I：

10.1080/07853890.2022.2067897

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer, and to encourage collaborations between researchers in North America and East African countries. To date, studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on the persistence of HPV, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP. It will now be determined how HPV testing fits into cervical cancer screening programs in Kenya and Uganda, how aflatoxin influences immunological control of HIV, how HPV alters certain genes involved in the growth of tumours in HIV-infected women. Although there have been challenges in performing this research, with time, this work should help to reduce the burden of cervical cancer and other cancers related to HIV infection in people living in sub-Saharan Africa, as well as optimized processes to better facilitate research as well as patient autonomy and safety. KEY MESSAGES The East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer. Collaborations have been established between researchers in North America and East African countries for these studies. Studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on HPV detection, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP.

引用

页码：1202 / 1211

页数：10

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