Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis

被引：13

作者：

Ye, Wen-Chu ^{[1
]}

Huang, Shi-Feng ^{[1
]}

Hou, Lian-Jie ^{[1
]}

Long, Hai-Jiao ^{[1
,2
]}

Yin, Kai ^{[3
]}

Hu, Ching Yuan ^{[4
]}

Zhao, Guo-Jun ^{[1
]}

机构：

[1] Guangzhou Med Univ, Qingyuan Peoples Hosp, Affiliated Hosp 6, Qingyuan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Changsha, Peoples R China

[3] Guilin Med Univ, Affiliated Hosp 2, Guangxi Key Lab Diabet Syst Med, Guilin, Peoples R China

[4] Univ Hawaii Manoa, Coll Trop Agr & Human Resources, Dept Human Nutr Food & Anim Sci, Honolulu, HI 96822 USA

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

关键词：

cholesterol homeostasis; lncRNAs; liver disease; lipid-related diseases; cardiovascular disease; LONG NONCODING RNA; UP-REGULATION; PROMOTES ATHEROSCLEROSIS; INFLAMMATORY RESPONSE; HEPATIC LIPOGENESIS; INSULIN-RESISTANCE; LIPID-METABOLISM; CANCER; MALAT1; CONTRIBUTES;

D O I：

10.3389/fcvm.2021.688546

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maintaining cholesterol homeostasis is essential for normal cellular and systemic functions. Long non-coding RNAs (lncRNAs) represent a mechanism to fine-tune numerous biological processes by controlling gene expression. LncRNAs have emerged as important regulators in cholesterol homeostasis. Dysregulation of lncRNAs expression is associated with lipid-related diseases, suggesting that manipulating the lncRNAs expression could be a promising therapeutic approach to ameliorate liver disease progression and cardiovascular disease (CVD). However, given the high-abundant lncRNAs and the poor genetic conservation between species, much work is required to elucidate the specific role of lncRNAs in regulating cholesterol homeostasis. In this review, we highlighted the latest advances in the pivotal role and mechanism of lncRNAs in regulating cholesterol homeostasis. These findings provide novel insights into the underlying mechanisms of lncRNAs in lipid-related diseases and may offer potential therapeutic targets for treating lipid-related diseases.

引用

页数：13

共 148 条

[81] Small molecule inhibition of Ewing sarcoma cell growth via targeting the long non coding RNA HULC [J].

Mercatelli, Neri ;

Fortini, Diana ;

Palombo, Ramona ;

Paronetto, Maria Paola .

CANCER LETTERS, 2020, 469 :111-123

[82] Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus [J].

Mohamadi, Mahroo ;

Ghaedi, Hamid ;

Kazerouni, Faranak ;

Omidvar, Maryam Erfanian ;

Kalbasi, Saeid ;

Shanaki, Mehrnoosh ;

Miraalamy, Ghasem ;

Rahimipour, Ali .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2019, 79 (07) :519-523

[83] Telmisartan enhances cholesterol eff lux from THP-1 macrophages by activating PPARγ [J].

Nakaya, Kazuhiro ;

Ayaori, Makoto ;

Hisada, Tetsuya ;

Sawada, Shojiro ;

Tanaka, Nobukiyo ;

Iwamoto, Noriyuki ;

Ogura, Masatsune ;

Yakushiji, Emi ;

Kusuhara, Masatoshi ;

Nakamura, Haruo ;

Ohsuzu, Fumitaka .

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2007, 14 (03) :133-141

[84] Long non-coding RNA CDKN2B-AS1 contributes to atherosclerotic plaque formation by forming RNA-DNA triplex in the CDKN2B promoter [J].

Ou, Minghui ;

Li, Xia ;

Zhao, Shibo ;

Cui, Shichao ;

Tu, Jie .

EBIOMEDICINE, 2020, 55

[85]

Pan JX, 2017, EUR REV MED PHARMACO, V21, P322

[86]

Pang JL, 2018, EUR REV MED PHARMACO, V22, P6991, DOI 10.26355/eurrev_201810_16170

[87] Mono-(2-Ethylhexyl)phthalate Regulates Cholesterol Efflux via MicroRNAs Regulated m6A RNA Methylation [J].

Park, Min Hi ;

Jeong, Eunae ;

Choudhury, Mahua .

CHEMICAL RESEARCH IN TOXICOLOGY, 2020, 33 (02) :461-469

[88] m6A RNA methylation promotes XIST-mediated transcriptional repression [J].

Patil, Deepak P. ;

Chen, Chun-Kan ;

Pickering, Brian F. ;

Chow, Amy ;

Jackson, Constanza ;

Guttman, Mitchell ;

Jaffrey, Samie R. .

NATURE, 2016, 537 (7620) :369-+

[89] Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives [J].

Poller, Wolfgang ;

Dimmeler, Stefanie ;

Heymans, Stephane ;

Zeller, Tanja ;

Haas, Jan ;

Karakas, Mahir ;

Leistner, David-Manuel ;

Jakob, Philipp ;

Nakagawa, Shinichi ;

Blankenberg, Stefan ;

Engelhardt, Stefan ;

Thum, Thomas ;

Weber, Christian ;

Meder, Benjamin ;

Hajjar, Roger ;

Landmesser, Ulf .

EUROPEAN HEART JOURNAL, 2018, 39 (29) :2704-+

[90] Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression [J].

Qi, Lei S. ;

Larson, Matthew H. ;

Gilbert, Luke A. ;

Doudna, Jennifer A. ;

Weissman, Jonathan S. ;

Arkin, Adam P. ;

Lim, Wendell A. .

CELL, 2013, 152 (05) :1173-1183

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