In Vivo Visualization of Cranial Nerve Pathways in Humans Using Diffusion-Based Tractography

被引:82
作者
Hodaie, Mojgan [1 ,2 ]
Quan, Jessica [3 ]
Qixiang, David [1 ,2 ]
机构
[1] Univ Toronto, Div Neurosurg, Toronto, ON M5T 2S8, Canada
[2] Toronto Western Hosp, Toronto, ON M5T 2S8, Canada
[3] Queens Univ, Fac Med, Kingston, ON, Canada
关键词
Brainstem; Cranial nerves; Diffusion tensor imaging; Tractography; 3D Slicer; FIBER TRACKING; TENSOR TRACTOGRAPHY; PYRAMIDAL TRACT; BRAIN-STEM; ANATOMY; CONNECTIVITY; LESIONS; MICROSTRUCTURE;
D O I
10.1227/01.NEU.0000367613.09324.DA
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
OBJECTIVE: Diffusion-based tractography has emerged as a powerful technique for 3-dimensional tract reconstruction and imaging of white matter fibers; however, tractography of the cranial nerves has not been well studied. In particular, the feasibility of tractography of the individual cranial nerves has not been previously assessed. METHODS: 3-Tesla magnetic resonance imaging scans, including anatomic magnetic resonance images and diffusion tensor images, were used for this study. Tractography of the cranial nerves was performed using 3D Slicer software. The reconstructed 3-dimensional tracts were overlaid onto anatomic images for determination of location and course of intracranial fibers. RESULTS: Detailed tractography of the cranial nerves was obtained, although not all cranial nerves were imaged with similar anatomic fidelity. Some tracts were imaged in great detail (cranial nerves II, III, and V). Tractography of the optic apparatus allowed tracing from the optic nerve to the occipital lobe, including Meyer's loop. Trigeminal tractography allowed visualization of the gasserian ganglion as well as postganglionic fibers. Tractography of cranial nerve III shows the course of the fibers through the midbrain. Lower cranial nerves (cranial nerves IX, XI, and XII) could not be imaged well. CONCLUSION: Tractography of the cranial nerves is feasible, although technical improvements are necessary to improve the tract reconstruction of the lower cranial nerves. Detailed assessment of anatomy and the ability of overlaying the tracts onto anatomic magnetic resonance imaging scans is essential, particularly in the posterior fossa, to ensure that the tracts have been reconstructed with anatomic fidelity.
引用
收藏
页码:788 / 796
页数:9
相关论文
共 38 条
[1]   The basis of anisotropic water diffusion in the nervous system - a technical review [J].
Beaulieu, C .
NMR IN BIOMEDICINE, 2002, 15 (7-8) :435-455
[2]   Individual differences in white-matter microstructure reflect variation in functional connectivity during choice [J].
Boorman, Erie Dell ;
O'Shea, Jacinta ;
Sebastian, Catherine ;
Rushworth, Matthew F. S. ;
Johansen-Berg, Heidi .
CURRENT BIOLOGY, 2007, 17 (16) :1426-1431
[3]   A diffusion tensor imaging tractography atlas for virtual in vivo dissections [J].
Catani, Marco ;
Thiebaut de Schotten, Michel .
CORTEX, 2008, 44 (08) :1105-1132
[4]   Diffusion tensor imaging and white matter tractography in patients with brainstem lesions [J].
Chen, X. ;
Weigel, D. ;
Ganslandt, O. ;
Buchfelder, M. ;
Nimsky, C. .
ACTA NEUROCHIRURGICA, 2007, 149 (11) :1117-1131
[5]   Diffusion-based tractography in neurological disorders: concepts, applications, and future developments [J].
Ciccarelli, Olga ;
Catani, Marco ;
Johansen-Berg, Heidi ;
Clark, Chris ;
Thompson, Alan .
LANCET NEUROLOGY, 2008, 7 (08) :715-727
[6]   White matter fiber tracking in patients with space-occupying lesions of the brain: a new technique for neurosurgical planning? [J].
Clark, CA ;
Barrick, TR ;
Murphy, MM ;
Bell, BA .
NEUROIMAGE, 2003, 20 (03) :1601-1608
[7]   Imaging evaluation of cranial nerves 3, 4, and 6 [J].
Eisenkraft, B ;
Ortiz, AO .
SEMINARS IN ULTRASOUND CT AND MRI, 2001, 22 (06) :488-501
[8]   The oculomotor cistern: Anatomy and high-resolution imaging [J].
Everton, K. L. ;
Rassner, U. A. ;
Osborn, A. G. ;
Harnsberger, H. R. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2008, 29 (07) :1344-1348
[9]   3T PROPELLER diffusion tensor fiber tractography: A feasibility study for cranial nerve fiber tracking [J].
Kabasawa H. ;
Masutani Y. ;
Aoki S. ;
Abe O. ;
Masumoto T. ;
Hayashi N. ;
Ohtomo K. .
Radiation Medicine, 2007, 25 (9) :462-466
[10]   Anatomical study of the trigeminal and facial cranial nerves with the aid of 3.0-tesla magnetic resonance imaging [J].
Kakizawa, Yukinari ;
Seguchi, Tatsuya ;
Kodama, Kunihiko ;
Ogiwara, Toshihiro ;
Sasaki, Tetsuo ;
Goto, Tetsuya ;
Hongo, Kazuhiro .
JOURNAL OF NEUROSURGERY, 2008, 108 (03) :483-490