Understanding Laboratory Testing for SARS-CoV-2

被引：3
作者：
Cheema, Ritu [1 ]
Blumberg, Dean A. [1 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Pediat, Div Pediat Infect Dis, Sacramento, CA 95817 USA
来源：
CHILDREN-BASEL | 2021年 / 8卷 / 05期
关键词：
SARS-CoV-2; COVID; pandemic; serology; nucleic acid amplification test; RT-PCR; rapid antigen test; antibody testing; point-of-care test;
D O I：
10.3390/children8050355
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The SARS-CoV-2 pandemic has impacted millions of lives worldwide. Molecular assays and serological tests have been approved under EUA (emergency use authorization) by the FDA (food and drug administration), given these unprecedented times. These tests are not only critical for confirming the clinical diagnosis and making therapeutic decisions but also play an important role in the understanding of the epidemiology of the pandemic. There is limited experience with currently available tests and differences may exist among tests even using similar technology. The focus of this review is to improve clinicians' understanding of SARS-CoV-2 test procedures including their limitations. We discuss the impact of different host and environmental factors on test results.
引用
收藏
页数：9
相关论文
共 30 条
  • [1] [Anonymous], 2020, FINDINGS INVESTIGATI
  • [2] Performance of Abbott ID Now COVID-19 Rapid Nucleic Acid Amplification Test Using Nasopharyngeal Swabs Transported in Viral Transport Media and Dry Nasal Swabs in a New York City Academic Institution
    Basu, Atreyee
    Zinger, Tatyana
    Inglima, Kenneth
    Woo, Kar-Mun
    Atie, Onome
    Yurasits, Lauren
    See, Benjamin
    Aguero-Rosenfeld, Maria E.
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (08)
  • [3] Rapid, Sensitive, and Specific Severe Acute Respiratory Syndrome Coronavirus 2 Detection: A Multicenter Comparison Between Standard Quantitative Reverse-Transcriptase Polymerase Chain Reaction and CRISPR-Based DETECTR
    Brandsma, Eelke
    Verhagen, Han J. M. P.
    van de Laar, Thijs J. W.
    Claas, Eric C. J.
    Cornelissen, Marion
    van den Akker, Emile
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (02) : 206 - 213
  • [4] Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity
    Chen, Weilie
    Lan, Yun
    Yuan, Xiaozhen
    Deng, Xilong
    Li, Yueping
    Cai, Xiaoli
    Li, Liya
    He, Ruiying
    Tan, Yizhou
    Deng, Xizi
    Gao, Ming
    Tang, Guofang
    Zhao, Lingzhai
    Wang, Jinlin
    Fan, Qinghong
    Wen, Chunyan
    Tong, Yuwei
    Tang, Yangbo
    Hu, Fengyu
    Li, Feng
    Tang, Xiaoping
    [J]. EMERGING MICROBES & INFECTIONS, 2020, 9 (01) : 469 - 473
  • [5] Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis
    Cheung, Ka Shing
    Hung, Ivan F. N.
    Chan, Pierre P. Y.
    Lung, K. C.
    Tso, Eugene
    Liu, Raymond
    Ng, Y. Y.
    Chu, Man Y.
    Chung, Tom W. H.
    Tam, Anthony Raymond
    Yip, Cyril C. Y.
    Leung, Kit-Hang
    Fung, Agnes Yim-Fong
    Zhang, Ricky R.
    Lin, Yansheng
    Cheng, Ho Ming
    Zhang, Anna J. X.
    To, Kelvin K. W.
    Chan, Kwok-H
    Yuen, Kwok-Y
    Leung, Wai K.
    [J]. GASTROENTEROLOGY, 2020, 159 (01) : 81 - 95
  • [6] Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection (Review)
    Dinnes, Jacqueline
    Deeks, Jonathan J.
    Adriano, Ada
    Berhane, Sarah
    Davenport, Clare
    Dittrich, Sabine
    Emperador, Devy
    Takwoingi, Yemisi
    Cunningham, Jane
    Beese, Sophie
    Dretzke, Janine
    di Ruffano, Lavinia Ferrante
    Harris, Isobel M.
    Price, Malcolm J.
    Taylor-Phillips, Sian
    Hooft, Lotty
    Leeflang, Mariska M. G.
    Spijker, Rene
    Van den Bruel, Ann
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2020, (08):
  • [7] Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR
    Fang, Yicheng
    Zhang, Huangqi
    Xie, Jicheng
    Lin, Minjie
    Ying, Lingjun
    Pang, Peipei
    Ji, Wenbin
    [J]. RADIOLOGY, 2020, 296 (02) : E115 - E117
  • [8] FDA, COR COVID 19 DIAGN T
  • [9] Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
    Guo, Li
    Ren, Lili
    Yang, Siyuan
    Xiao, Meng
    Chang, De
    Yang, Fan
    Dela Cruz, Charles S.
    Wang, Yingying
    Wu, Chao
    Xiao, Yan
    Zhang, Lulu
    Han, Lianlian
    Dang, Shengyuan
    Xu, Yan
    Yang, Qi-Wen
    Xu, Sheng-Yong
    Zhu, Hua-Dong
    Xu, Ying-Chun
    Jin, Qi
    Sharma, Lokesh
    Wang, Linghang
    Wang, Jianwei
    [J]. CLINICAL INFECTIOUS DISEASES, 2020, 71 (15) : 778 - 785
  • [10] Imai K., 2020, ANTIBODY RESPONSE PA, pCONT, DOI [10.1101/2020.11.20.20231696, DOI 10.1101/2020.11.20.20231696]
123