Predicting AID off-targets: A step forward

被引：4

作者：

Reynaud, Claude-Agnes

Weill, Jean-Claude

机构：

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2018年 / 215卷 / 03期

关键词：

SOMATIC HYPERMUTATION; B-CELLS;

D O I：

10.1084/jem.20180231

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of JEM, Alvarez-Prado et al. (https://doi.org/10.1084/jem.20171738) designed a DNA capture library allowing them to identify 275 genes targeted by AID in mouse germinal center B cells. Using the molecular features of these genes to feed a machine-learning algorithm, they determined that high-density RNA PolII and Spt5 binding-found in 2.3% of the genes-are the best predictors of AID specificity.

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收藏

页码：721 / 722

页数：2

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