Human Cord Blood Transplantation in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage: Functional Outcome Related to Neuroprotection in the Striatum

被引：123

作者：

Pimentel-Coelho, Pedro M. ^{[1
,2
]}

Magalhaes, Elizabeth S. ^{[3
]}

Lopes, Laudelino M. ^{[4
]}

deAzevedo, Leonardo C. ^{[3
]}

Santiago, Marcelo F. ^{[2
]}

Mendez-Otero, Rosalia ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, Inst Ciencias Biomed, BR-21949900 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Programa Terapia Celular, BR-21949900 Rio De Janeiro, Brazil

[3] Fiocruz MS, Inst Fernandes Figueira, BR-21045900 Rio De Janeiro, Brazil

[4] CPDT, Rio De Janeiro, Brazil

来源：

STEM CELLS AND DEVELOPMENT | 2010年 / 19卷 / 03期

关键词：

CENTRAL-NERVOUS-SYSTEM; IN-VITRO ISCHEMIA; STEM-CELLS; SELECTIVE VULNERABILITY; BEHAVIORAL DEFICITS; INJURY; STROKE; PROGENITORS; PHENOTYPE; DYSFUNCTION;

D O I：

10.1089/scd.2009.0049

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different models of central nervous system (CNS) damage, including stroke. We evaluated the possible therapeutic potential of HUCB in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic-ischemic (HI) brain damage. Our results demonstrated that intraperitoneal transplantation of HUCB, 3 h after the HI insult, resulted in better performance in two developmental sensorimotor reflexes, in the first week after the injury. We also showed a neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral cortex of treated animals. We suggest that HUCB transplantation might rescue striatal neurons from cell death after a neonatal HI injury resulting in better functional recovery.

引用

页码：351 / 358

页数：8

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