Human Cord Blood Transplantation in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage: Functional Outcome Related to Neuroprotection in the Striatum

被引：123
作者：
Pimentel-Coelho, Pedro M. [1 ,2 ]
Magalhaes, Elizabeth S. [3 ]
Lopes, Laudelino M. [4 ]
deAzevedo, Leonardo C. [3 ]
Santiago, Marcelo F. [2 ]
Mendez-Otero, Rosalia [2 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, Inst Ciencias Biomed, BR-21949900 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Programa Terapia Celular, BR-21949900 Rio De Janeiro, Brazil
[3] Fiocruz MS, Inst Fernandes Figueira, BR-21045900 Rio De Janeiro, Brazil
[4] CPDT, Rio De Janeiro, Brazil
来源：
STEM CELLS AND DEVELOPMENT | 2010年 / 19卷 / 03期
关键词：
CENTRAL-NERVOUS-SYSTEM; IN-VITRO ISCHEMIA; STEM-CELLS; SELECTIVE VULNERABILITY; BEHAVIORAL DEFICITS; INJURY; STROKE; PROGENITORS; PHENOTYPE; DYSFUNCTION;
D O I：
10.1089/scd.2009.0049
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different models of central nervous system (CNS) damage, including stroke. We evaluated the possible therapeutic potential of HUCB in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic-ischemic (HI) brain damage. Our results demonstrated that intraperitoneal transplantation of HUCB, 3 h after the HI insult, resulted in better performance in two developmental sensorimotor reflexes, in the first week after the injury. We also showed a neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral cortex of treated animals. We suggest that HUCB transplantation might rescue striatal neurons from cell death after a neonatal HI injury resulting in better functional recovery.
引用
收藏
页码：351 / 358
页数：8
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