Tranexamic acid in pediatric trauma: why not?

被引：39

作者：

Beno, Suzanne ^{[1
]}

Ackery, Alun D. ^{[2
]}

Callum, Jeannie ^{[3
]}

Rizoli, Sandro ^{[2
]}

机构：

[1] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[2] St Michaels Hosp, Toronto, ON M5B 1W8, Canada

[3] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

来源：

CRITICAL CARE | 2014年 / 18卷 / 04期

关键词：

ANTIFIBRINOLYTIC DRUGS; INDEPENDENT PREDICTOR; CARDIAC-SURGERY; BRAIN-INJURY; COAGULOPATHY; CHILDREN; MORTALITY; TRANSFUSION; ADMISSION; EFFICACY;

D O I：

10.1186/cc13965

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Trauma is a leading cause of death in pediatrics. Currently, no medical treatment exists to reduce mortality in the setting of pediatric trauma; however, this evidence does exist in adults. Bleeding and coagulopathy after trauma increases mortality in both adults and children. Clinical research has demonstrated a reduction in mortality with early use of tranexamic acid in adult trauma patients in both civilian and military settings. Tranexamic acid used in the perioperative setting safely reduces transfusion requirements in children. This article compares the hematologic response to trauma between children and adults, and explores the potential use of tranexamic acid in pediatric hemorrhagic trauma.

引用

收藏

页数：5

相关论文

共 40 条

[21]

Manji RA, 2012, CAN J ANESTH, V59, P6, DOI 10.1007/s12630-011-9618-z

[22]

McLeod I.M, 2013, J SPINAL DISORD TECH

[23] Acute coagulopathy and early deaths post major trauma [J].

Mitra, Biswadev ;

Cameron, Peter A. ;

Mori, Alfredo ;

Fitzgerald, Mark .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2012, 43 (01) :22-25

[24] Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study [J].

Morrison, Jonathan J. ;

Dubose, Joseph J. ;

Rasmussen, Todd E. ;

Midwinter, Mark J. .

ARCHIVES OF SURGERY, 2012, 147 (02) :113-119

[25] High-Dose Tranexamic Acid Is Associated with Nonischemic Clinical Seizures in Cardiac Surgical Patients [J].

Murkin, John M. ;

Falter, Florian ;

Granton, Jeff ;

Young, Bryan ;

Burt, Christiana ;

Chu, Michael .

ANESTHESIA AND ANALGESIA, 2010, 110 (02) :350-353

[26] Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: A systematic review [J].

Naoulou, Becky ;

Tsai, Ming C. .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2012, 91 (05) :529-537

[27] Enzyme-controlling medicines: Introduction [J].

Okamoto, S ;

Hijikata-Okunomiya, A ;

Wanaka, K ;

Okada, Y ;

Okamoto, U .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1997, 23 (06) :493-501

[28] Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitals [J].

Patregnani, Jason T. ;

Borgman, Matthew A. ;

Maegele, Marc ;

Wade, Charles E. ;

Blackbourne, Lorne H. ;

Spinella, Philip C. .

PEDIATRIC CRITICAL CARE MEDICINE, 2012, 13 (03) :273-277

[29] Glasgow Coma Scale as a predictor for hemocoagulative disorders after blunt pediatric traumatic brain injury [J].

Peiniger, Sigune ;

Nienaber, Ulrike ;

Lefering, Rolf ;

Braun, Maximilian ;

Wafaisade, Arasch ;

Borgman, Matthew A. ;

Spinella, Philip C. ;

Maegele, Marc .

PEDIATRIC CRITICAL CARE MEDICINE, 2012, 13 (04) :455-460

[30] Tranexamic Acid-Induced Toxic Epidermal Necrolysis [J].

Pretel Irazabal, Maider ;

Marques Martin, Laura ;

Aguado Gil, Leyre ;

Idoate Gastearena, Miguel Angel .

ANNALS OF PHARMACOTHERAPY, 2013, 47 (03) :E16-U30

← 1 2 3 4 →