Inducible nitric oxide synthase does not affect resolution of murine chlamydial genital tract infections or eradication of chlamydiae in primary murine cell culture

被引：38

作者：

Ramsey, KH

Miranpuri, GS

Poulsen, CE

Marthakis, NB

Braune, LM

Byrne, GI

机构：

[1] Midwestern State Univ, Chicago Coll Osteopath Med, Dept Microbiol, Downers Grove, IL 60515 USA

[2] Univ Wisconsin, Sch Med, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 02期

关键词：

D O I：

10.1128/IAI.66.2.835-838.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma interferon restricted chlamydial growth in the absence of nitric oxide. From these results, iNOS activity is unnecessary for the resolution of chlamydial genital tract infections in mice and inhibition of chlamydial growth in culture.

引用

收藏

页码：835 / 838

页数：4

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