The Therapeutic Applications of Exosomes in Different Types of Diseases: A Review

被引:9
作者
Hosseini, Mohammadbagher [1 ]
Roshangar, Leila [2 ]
Raeisi, Sina [1 ]
Ghahremanzadeh, Kazem [1 ]
Negargar, Sohrab [3 ]
Tarmahi, Vahid [1 ]
Hosseini, Vahid [4 ]
Raeisi, Mohammadreza [1 ]
Rahimi, Elnaz [3 ]
Ebadi, Zakiyeh [1 ]
机构
[1] Tabriz Univ Med Sci, Pediat Hlth Res Ctr, Sheshgelan St,POB 5136735886, Tabriz, Iran
[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Fac Med, Dept Biochem & Clin Labs, Tabriz, Iran
关键词
Exosome; cancer; cardiovascular diseases; neurologic diseases; liver diseases; kidney diseases; CELL-DERIVED EXOSOMES; STEM-CELLS; MICROVESICLES PROTECT; ANTICANCER DRUGS; CARDIAC-FUNCTION; DELIVERY; BRAIN; MYOCARDIUM; ANGIOGENESIS; REGENERATION;
D O I
10.2174/1566524020666200610164743
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Exosomes are nano-sized vesicles secreted by nearly all cells and have received massive attention recently. In addition to their roles in pathophysiological processes and diagnostic evaluations, recently, several studies have applied exosomes to design novel therapeutic applications. Exosomes can be derived from a variety of cells and tissues and based on the source, they can carry different native contents such as DNAs, non-coding small RNAs, mRNAs, and proteins. They can also be engineered by adding desirable agents including specific biomolecules or drugs. Both forms can be therapeutically used for delivering their cargoes to the target cells and desirably alter their functions. The present study aimed to provide a comprehensive review of the various studies which applied exosomes as a therapeutic tool in the treatment of different types of diseases including cancer, cardiovascular, neurologic, psychiatric, liver, and kidney diseases.
引用
收藏
页码:87 / 95
页数:9
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