Copper-Catalyzed Remote sp3 C-H Chlorination of Alkyl Hydroperoxides

被引：73

作者：

Kundu, Rituparna ^{[1
]}

Ball, Zachary T. ^{[1
]}

机构：

[1] Rice Univ, Dept Chem, Houston, TX 77005 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 11期

关键词：

LIVING RADICAL POLYMERIZATION; ION-INDUCED DECOMPOSITION; ATOM-TRANSFER; TRANSANNULAR REACTIONS; BOND FUNCTIONALIZATION; CUPRIC ION; OXIDATION; CHEMISTRY; STEROIDS; TRANSFORMATIONS;

D O I：

10.1021/ol100472t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed methodology to functionalize remote sp(3) C-H bonds in alkyl hydroperoxides is presented. The atom-transfer chlorination utilizes simple ammonium chloride salts as the chlorine source, and the internal redox process requires no external redox reagents.

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页码：2460 / 2463

页数：4

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