Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

被引：398

作者：

Paskeh, Mahshid Deldar Abad ^{[1
,2
]}

Entezari, Maliheh ^{[1
,2
]}

Mirzaei, Sepideh ^{[3
]}

Zabolian, Amirhossein ^{[4
]}

Saleki, Hossein ^{[4
]}

Naghdi, Mohamad Javad ^{[4
]}

Sabet, Sina ^{[4
]}

Khoshbakht, Mohammad Amin ^{[4
]}

Hashemi, Mehrdad ^{[1
,2
]}

Hushmandi, Kiavash ^{[5
]}

Sethi, Gautam ^{[6
,7
]}

Zarrabi, Ali ^{[8
]}

Kumar, Alan Prem ^{[6
,7
]}

Tan, Shing Cheng ^{[9
]}

Papadakis, Marios ^{[10
]}

Alexiou, Athanasios ^{[11
,16
]}

Islam, Md Asiful ^{[12
,17
]}

Mostafavi, Ebrahim ^{[13
,14
]}

Ashrafizadeh, Milad ^{[15
]}

机构：

[1] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Genet, Tehran Med Sci, Tehran, Iran

[2] Islamic Azad Univ, Farhikhtegan Med Convergence Sci Res Ctr, Farhikhtegan Hosp Tehran Med Sci, Tehran, Iran

[3] Islamic Azad Univ, Dept Biol, Fac Sci, Sci & Res Branch, Tehran, Iran

[4] Islamic Azad Univ, Young Researchers & Elite Club, Tehran Med Sci, Tehran, Iran

[5] Univ Tehran, Div Epidemiol, Dept Food Hyg & Qual Control, Fac Vet Med, Tehran, Iran

[6] Natl Univ Singapore, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore 117600, Singapore

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, NUS Ctr Canc Res N2CR, Singapore 117597, Singapore

[8] Istinye Univ, Dept Biomed Engn, Fac Engn & Nat Sci, TR-34396 Istanbul, Turkey

[9] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst, Kuala Lumpur, Malaysia

[10] Univ Witten Herdecke, Dept Surg 2, Univ Hosp Witten Herdecke, Heusnerstr 40, D-42283 Wuppertal, Germany

[11] Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, Australia

[12] Univ Sains Malaysia, Dept Haematol, Sch Med Sci, Kubang Kerian, Kelantan, Malaysia

[13] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[14] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[15] Sabanci Univ, Fac Engn & Nat Sci, Orta Mahalle,Univ Caddesi 27, Istanbul, Turkey

[16] AFNP Med Austria, Vienna, Austria

[17] Univ Birmingham, Inst Metab & Syst Res, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2022年 / 15卷 / 01期

基金：

英国医学研究理事会;

关键词：

Exosome; Cancer; Immunotherapy; Non-coding RNA; Biomarker; Prognosis; CELL-DERIVED EXOSOMES; LONG NONCODING RNAS; EPITHELIAL-MESENCHYMAL TRANSITION; PANCREATIC-CANCER; BREAST-CANCER; GASTRIC-CANCER; STEM-CELLS; COLORECTAL-CANCER; LUNG-CANCER; IN-VITRO;

D O I：

10.1186/s13045-022-01305-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment.

引用

页数：39

共 512 条

[1] Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers [J].