Vitamin E Succinate Inhibits the Growth of Human Gastric Cancer Cells

被引:0
作者
Lan, Tingzhu [1 ]
Guan, Xiaohui [1 ]
机构
[1] BeiHua Univ, Dept Gastroenterol, Affiliated Hosp, Jilin 132012, Jilin, Peoples R China
关键词
Vitamin E Succinate; human gastric cancer cells; promote apoptosis; inhibitory effect; CYCLE ARREST; APOPTOSIS; INVASION;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Gastric cancer is the most common malignant tumor disease in the human digestive system. It ranks first in the incidence of cancer-related diseases in China. It is a serious threat to the health of Chinese people. Vitamin E Succinate is a natural Vitamin E derivative and has been confirmed to have an inhibitory effect on tumor cell growth. Based on this, the article explores the effect of Vitamin E Succinate on inhibiting the growth of human gastric cancer cells and aims to provide a reference for the clinical diagnosis and treatment of gastric cancer. This article first systematically introduces Vitamin E Succinate and the related theoretical knowledge of gastric cancer and lays a sufficient theoretical foundation for the following research on Vitamin E Succinate inhibiting the growth of human gastric cancer cells and inducing apoptosis of gastric cancer cells. The human gastric cancer cell specimens and Vitamin E Succinate solution were formulated and the effect of Vitamin E Succinate on the growth of human gastric cancer cells was tested. According to the concentration of Vitamin E Succinate, the gastric cancer cells in the experiment were divided into Vitamin E Succinate 10 mg/ml dose group, Vitamin E Succinate 10 mg/ml dose group, Vitamin E Succinate 15 mg/ml dose group and the blank control group, the growth curve of gastric cancer cells, cell colony determination, cell division index determination and cell 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide detection and analysis were used to compare the changes in cell growth between different dose groups; the final result is that Vitamin E Succinate has a significant inhibitory effect on the growth of gastric cancer cells (p<0.05) and as the dose concentration increases and the treatment time increases, its inhibitory effect on the cells is more significant.
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收藏
页码:346 / 353
页数:8
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