Vitamin E Succinate Inhibits the Growth of Human Gastric Cancer Cells

被引:0
作者
Lan, Tingzhu [1 ]
Guan, Xiaohui [1 ]
机构
[1] BeiHua Univ, Dept Gastroenterol, Affiliated Hosp, Jilin 132012, Jilin, Peoples R China
关键词
Vitamin E Succinate; human gastric cancer cells; promote apoptosis; inhibitory effect; CYCLE ARREST; APOPTOSIS; INVASION;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Gastric cancer is the most common malignant tumor disease in the human digestive system. It ranks first in the incidence of cancer-related diseases in China. It is a serious threat to the health of Chinese people. Vitamin E Succinate is a natural Vitamin E derivative and has been confirmed to have an inhibitory effect on tumor cell growth. Based on this, the article explores the effect of Vitamin E Succinate on inhibiting the growth of human gastric cancer cells and aims to provide a reference for the clinical diagnosis and treatment of gastric cancer. This article first systematically introduces Vitamin E Succinate and the related theoretical knowledge of gastric cancer and lays a sufficient theoretical foundation for the following research on Vitamin E Succinate inhibiting the growth of human gastric cancer cells and inducing apoptosis of gastric cancer cells. The human gastric cancer cell specimens and Vitamin E Succinate solution were formulated and the effect of Vitamin E Succinate on the growth of human gastric cancer cells was tested. According to the concentration of Vitamin E Succinate, the gastric cancer cells in the experiment were divided into Vitamin E Succinate 10 mg/ml dose group, Vitamin E Succinate 10 mg/ml dose group, Vitamin E Succinate 15 mg/ml dose group and the blank control group, the growth curve of gastric cancer cells, cell colony determination, cell division index determination and cell 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide detection and analysis were used to compare the changes in cell growth between different dose groups; the final result is that Vitamin E Succinate has a significant inhibitory effect on the growth of gastric cancer cells (p<0.05) and as the dose concentration increases and the treatment time increases, its inhibitory effect on the cells is more significant.
引用
收藏
页码:346 / 353
页数:8
相关论文
共 50 条
[31]   Vitamin E succinate promotes breast cancer tumor dormancy [J].
Malafa, MP ;
Neitzel, LT .
JOURNAL OF SURGICAL RESEARCH, 2000, 93 (01) :163-170
[32]   Astragaloside IV inhibits human colorectal cancer cell growth [J].
Sun, Peng ;
Liu, Yan ;
Wang, Qun ;
Zhang, Baichao .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2019, 24 :597-606
[33]   RKIP inhibits the malignant phenotypes of gastric cancer cells [J].
Zhang, X. M. ;
Gu, H. ;
Yan, L. ;
Zhang, G. Y. .
NEOPLASMA, 2013, 60 (02) :196-202
[34]   Autophagy Induced by Naftopidil Inhibits Apoptosis of Human Gastric Cancer Cells [J].
Nakamura, Azumi ;
Matsunaga, Wataru ;
Gotoh, Akinobu .
ANTICANCER RESEARCH, 2018, 38 (02) :803-809
[35]   Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis [J].
Malafa, MP ;
Fokum, FD ;
Andoh, J ;
Neitzel, LT ;
Bandyopadhyay, S ;
Zhan, R ;
Iiizumi, M ;
Furuta, E ;
Horvath, E ;
Watabe, K .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (10) :2441-2447
[36]   Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway [J].
Li, Jing ;
Shen, Lin ;
Lu, Fu-rong ;
Qin, You ;
Chen, Rui ;
Li, Jia ;
Li, Yan ;
Zhan, Han-zi ;
He, Yuan-qiao .
ACTA PHARMACOLOGICA SINICA, 2012, 33 (02) :242-249
[37]   Huachansu Capsule inhibits the proliferation of human gastric cancer cells via Akt/mTOR pathway [J].
Ni, Tengyang ;
Wang, Haibo ;
Li, Dan ;
Tao, Li ;
Lv, Mengying ;
Jin, Feng ;
Wang, Weimin ;
Feng, Jun ;
Qian, Yayun ;
Sunagawa, Masataka ;
Liu, Yanqing .
BIOMEDICINE & PHARMACOTHERAPY, 2019, 118
[38]   Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells [J].
Zhao, BH ;
Yu, WP ;
Qian, M ;
SimmonsMenchaca, M ;
Brown, P ;
Birrer, MJ ;
Sanders, BG ;
Kline, K .
MOLECULAR CARCINOGENESIS, 1997, 19 (03) :180-190
[39]   Gastrokine 1 transferred by gastric cancer exosomes inhibits growth and invasion of gastric cancer cells in vitro and in vivo [J].
Tian, Lingling ;
Tang, Li ;
Li, Xu ;
Huang, Liuye .
JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2024, 18 (03)
[40]   Total saponins from Tupistra chinensis baker inhibits growth of human gastric cancer cells in vitro and in vivo [J].
Wang, Zhe ;
Xu, Jingwen ;
Wang, Yihai ;
Xiang, Limin ;
He, Xiangjiu .
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 278