Regulation and roles of CD26/DPPIV in hematopoiesis and diseases

被引：22

作者：

Serej, Zeynab Aliyari ^{[1
]}

Kalan, Abbas Ebrahimi ^{[2
,3
]}

Mehdipour, Ahmad ^{[4
]}

Charoudeh, Hojjatollah Nozad ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Appl Cell Sci Dept, Sch Adv Med Sci, Tabriz, Iran

[2] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Neurosci Dept, Tabriz, Iran

[4] Tabriz Univ Med Sci, Sch Adv Med Sci, Tissue Engn Dept, Tabriz, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 91卷

关键词：

CD26/DPPIV; Cancer; Autoimmune diseases; UCB; Cytokines; DIPEPTIDYL-PEPTIDASE-IV; PERIPHERAL-BLOOD; PROGENITOR CELLS; CD26; EXPRESSION; SOLUBLE CD26; T-CELLS; ACTIVATION; SURFACE; IV/CD26; PROTEIN;

D O I：

10.1016/j.biopha.2017.04.074

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Dipeptidyl peptidase IV (DPPIV),(1) on the surface of certain cells, where it is also referred to as CD26, is involved in a vast majority of biological and pathological processes. CD26/DPPIV function contributes to cancer and tumor metastasis as well as inhibition of its expression which alters the expression of immune response-related genes. CD26/DPPIV is a widely distributed multifunctional integral membrane and secreted protein that is defined as early predictive biomarker in HIV, cancer and autoimmunity diseases like diabetes and multiple sclerosis. CD26/DPPIV-chemokine interaction may have a functional role in Tcells and overall immune function. It is expressed at low density on resting T cells, but is upregulated with T cell activation. In this review, we summarize valuable information about detailed biological aspects and pharmacokinetic characteristics of CD26/DPPIV and its clinical efficacy, focusing particularly on the role of CD26/DPPIV in immunological and non-immunological diseases. We also describe our recent work about umbilical cord blood (UCB)(2) hematopoietic stem cell transplantation strategies in which identified CD26+ cells can be differentiated to immune cells under certain culture condition. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：88 / 94

页数：7

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