ZnO size and shape effect on antibacterial activity and cytotoxicity profile

被引：261

作者：

Babayevska, Nataliya ^{[1
]}

Przysiecka, Lucja ^{[1
]}

Iatsunskyi, Igor ^{[1
]}

Nowaczyk, Grzegorz ^{[1
]}

Jarek, Marcin ^{[1
]}

Janiszewska, Ewa ^{[2
]}

Jurga, Stefan ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, NanoBioMed Ctr, Wszechnicy Piastowskiej 3, PL-61614 Poznan, Poland

[2] Adam Mickiewicz Univ, Fac Chem, Uniwersytetu Poznanskiego 8, PL-61614 Poznan, Poland

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

ZINC-OXIDE NANOPARTICLES; SURFACE-AREA; MORPHOLOGY; NANOSTRUCTURES; PERFORMANCE; SUSPENSIONS; TETRAPODS; SILVER;

D O I：

10.1038/s41598-022-12134-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of our work was the synthesis of ZnO nano- and microparticles and to study the effect of shapes and sizes on cytotoxicity towards normal and cancer cells and antibacterial activity toward two kinds of bacteria. We fabricated ZnO nano- and microparticles through facile chemical and physical routes. The crystal structure, morphology, textural properties, and photoluminescent properties were characterized by powder X-ray diffraction, electron microscopies, nitrogen adsorption/desorption measurements, and photoluminescence spectroscopy. The obtained ZnO structures were highly crystalline and monodispersed with intensive green emission. ZnO NPs and NRs showed the strongest antibacterial activity against Escherichia coli and Staphylococcus aureus compared to microparticles due to their high specific surface area. However, the ZnO HSs at higher concentrations also strongly inhibited bacterial growth. S. aureus strain was more sensitive to ZnO particles than the E. coli. ZnO NPs and NRs were more harmful to cancer cell lines than to normal ones at the same concentration.

引用

页数：13

共 64 条

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