Hematopoietic Cell Transplantation in the Treatment of Adult Acute Lymphoblastic Leukemia: Updated 2019 Evidence-Based Review from the American Society for Transplantation and Cellular Therapy

被引：74

作者：

DeFilipp, Zachariah ^{[1
]}

Advani, Anjali S. ^{[2
]}

Bachanova, Veronika ^{[3
]}

Cassaday, Ryan D. ^{[4
,5
]}

Deangelo, Daniel J. ^{[6
]}

Kebriaei, Partow ^{[7
]}

Rowe, Jacob M. ^{[8
]}

Seftel, Matthew D. ^{[9
]}

Stock, Wendy ^{[10
]}

Tallman, Martin S. ^{[11
]}

Fanning, Suzanne ^{[12
]}

Inamoto, Yoshihiro ^{[13
]}

Kansagra, Ankit ^{[14
]}

Johnston, Laura ^{[15
]}

Nagler, Arnon ^{[16
]}

Sauter, Craig S. ^{[17
]}

Savani, Bipin N. ^{[18
]}

Perales, Miguel-Angel ^{[17
]}

Carpenter, Paul A. ^{[4
,19
]}

Larson, Richard A. ^{[10
]}

Weisdorf, Daniel ^{[3
]}

机构：

[1] Massachusetts Gen Hosp, Blood & Marrow Transplant Program, 55 Fruit St,Zero Emerson,Suite 118,Off 134, Boston, MA 02114 USA

[2] Cleveland Clin, Taussig Canc Inst, Dept Med Oncol & Hematol, Cleveland, OH 44106 USA

[3] Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol Transplantat, Minneapolis, MN 55455 USA

[4] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA

[5] Univ Washington, Dept Med, Seattle, WA USA

[6] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

[8] Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel

[9] Univ Manitoba, CancerCare Manitoba, Winnipeg, MB, Canada

[10] Univ Chicago, Ctr Comprehens Canc, Dept Hematol & Oncol, Chicago, IL 60637 USA

[11] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY USA

[12] Greenville Hlth Syst Canc Inst, Hematol & Med Oncol, Greenville, SC USA

[13] Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[14] Univ Texas Southwestern Med Ctr Dallas, Dept Hematol & Oncol, Dallas, TX 75390 USA

[15] Stanford Univ, Med Ctr, Dept Med, Stanford, CA 94305 USA

[16] Chaim Sheba Med Ctr, Hematol & Bone Marrow Transplantat Div, Tel Hashomer, Israel

[17] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Adult Bone Marrow Transplant Serv, New York, NY USA

[18] Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA

[19] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2019年 / 25卷 / 11期

关键词：

Acute lymphoblastic leukemia; Allogeneic hematopoietic cell transplantation; Autologous stem cell transplantation; Guideline; Evidence-based review; MINIMAL RESIDUAL DISEASE; CORD-BLOOD TRANSPLANTATION; TYROSINE KINASE INHIBITORS; TOTAL-BODY IRRADIATION; TERM-FOLLOW-UP; MYELOABLATIVE ALLOGENEIC TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; NERVOUS-SYSTEM INVOLVEMENT; 1ST COMPLETE REMISSION; REDUCED-INTENSITY;

D O I：

10.1016/j.bbmt.2019.08.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of hematopoietic cell transplantation (HCT) in adults with acute lymphoblastic leukemia (ALL) is reviewed and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the recommendations. A panel of ALL experts developed consensus on the treatment recommendations based on the evidence. Allogeneic HCT offers a survival benefit in selected patients with ALL, and this review summarizes the standard indications as well as the areas of controversy. There is now greater experience with pediatric-inspired chemotherapy regimens that has transformed upfront therapy for adult ALL, resulting in higher remission rates and overall survival. This in turn has increased the equipoise around decision making for ALL in first complete remission (CR1) when there is no measurable residual disease (MRD) at the end of induction and/or consolidation. Randomized studies are needed for adults with ALL to compare allogeneic HCT in CR1 with pediatric-inspired chemotherapy alone. Indications for transplantation in the evolving landscape of MRD assessments and novel targeted and immune therapeutics remain important areas of investigation. (C) 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.

引用

页码：2113 / 2123

页数：11

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