1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication

被引：7

作者：

Nikitenko, N. A. ^{[1
]}

Gureeva, E. S. ^{[2
]}

Ozerov, A. A. ^{[2
]}

Tukhvatulin, A. I.

Izhaeva, F. M. ^{[1
]}

Prassolov, V. S. ^{[3
]}

Deryabin, P. G. ^{[1
]}

Novikov, M. S. ^{[2
]}

Logunov, D. Y. ^{[1
]}

机构：

[1] NF Gamaleya Fed Natl Res Ctr Epidemiol & Microbio, Gamaleya Str 18, Moscow 123098, Russia

[2] Volgograd State Med Univ, Pavshih Bortsov Sq 1, Volgograd 400131, Russia

[3] Russian Acad Sci, Engelhardt Inst Mol Biol, Vavilova Str 32, Moscow 119991, Russia

来源：

ACTA NATURAE | 2018年 / 10卷 / 02期

关键词：

Human adenovirus; 5-aminouracil derivatives; adenovirus replication; inhibitors of adenovirus replication; SPECIES D ADENOVIRUSES; REAL-TIME PCR; EPIDEMIC KERATOCONJUNCTIVITIS; IDENTIFICATION; ASSAY; DNA;

D O I：

10.32607/20758251-2018-10-2-58-64

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.

引用

页码：58 / 64

页数：7

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