Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation

被引：40
作者：
Bailey, J. C. [1 ]
Feelisch, M. [2 ]
Horowitz, J. D. [3 ]
Frenneaux, M. P. [4 ]
Madhani, M. [1 ]
机构：
[1] Univ Birmingham, Coll Med & Dent Sci, Ctr Cardiovasc Sci, Birmingham B15 2TT, W Midlands, England
[2] Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England
[3] Queen Elizabeth Hosp, Adelaide, SA, Australia
[4] Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland
来源：
PHARMACOLOGY & THERAPEUTICS | 2014年 / 144卷 / 03期
基金：
英国医学研究理事会;
关键词：
Nitrate; Nitrite; Nitric oxide; Vasodilatation; Heart failure; RED-BLOOD-CELLS; MITOCHONDRIAL ALDEHYDE DEHYDROGENASE; VASCULAR ENDOTHELIAL DYSFUNCTION; HEALTHY-VOLUNTEERS INVOLVEMENT; LOW-DENSITY-LIPOPROTEIN; OXIDE SYNTHASE ACTIVITY; N-NITROSO COMPOUNDS; DIETARY NITRATE; SODIUM-NITRITE; IN-VIVO;
D O I：
10.1016/j.pharmthera.2014.06.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure. (C) 2014 Elsevier Inc All rights reserved.
引用
收藏
页码：303 / 320
页数：18
相关论文
共 223 条
  • [1] Dietary nitrate facilitates an acetazolamide-induced increase in cerebral blood flow during visual stimulation
    Aamand, Rasmus
    Ho, Yi-Ching Lynn
    Dalsgaard, Thomas
    Roepstorff, Andreas
    Lund, Torben E.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2014, 116 (03) : 267 - 273
  • [2] Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation
    Aamand, Rasmus
    Dalsgaard, Thomas
    Jensen, Frank B.
    Simonsen, Ulf
    Roepstorff, Andreas
    Fago, Angela
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2009, 297 (06): : H2068 - H2074
  • [3] Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase-Dependent Manner in Diabetic Mice
    Abudukadier, Abulizi
    Fujita, Yoshihito
    Obara, Akio
    Ohashi, Akiko
    Fukushima, Toru
    Sato, Yuichi
    Ogura, Masahito
    Nakamura, Yasuhiko
    Fujimoto, Shimpei
    Hosokawa, Masaya
    Hasegawa, Hiroyuki
    Inagaki, Nobuya
    [J]. DIABETES, 2013, 62 (09) : 3033 - 3043
  • [4] Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall
    Alzawahra, Wael F.
    Talukder, M. A. Hassan
    Liu, Xiaoping
    Samouilov, Alexandre
    Zweier, Jay L.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (02): : H499 - H508
  • [5] NITRIC-OXIDE SYNTHESIZED FROM L-ARGININE REGULATES VASCULAR TONE IN THE CORONARY CIRCULATION OF THE RABBIT
    AMEZCUA, JL
    PALMER, RMJ
    DESOUZA, BM
    MONCADA, S
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (04) : 1119 - 1124
  • [6] Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension
    Amin, Ali
    Choi, Soo-Kyoung
    Osman-Elazeik, Yehia
    El-Din, Nariman K. Badr
    Kevil, Christopher G.
    Navar, Louis G.
    Kadowitz, Philip
    Trebak, Mohamed
    Matrougui, Khalid
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2012, 464 (06): : 583 - 592
  • [7] An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
    Angelo, Michael
    Singel, David J.
    Stamler, Jonathan S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (22) : 8366 - 8371
  • [8] A clinical trial of the effects of dietary patterns on blood pressure
    Appel, LJ
    Moore, TJ
    Obarzanek, E
    Vollmer, WM
    Svetkey, LP
    Sacks, FM
    Bray, GA
    Vogt, TM
    Cutler, JA
    Windhauser, MM
    Lin, PH
    Karanja, N
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) : 1117 - 1124
  • [9] Arai A., 2006, AM J PHYSIOL-HEART C
  • [10] ARCHER MC, 1989, CANCER SURV, V8, P241
12345678910