Globostelletins A-I, cytotoxic isomalabaricane derivatives from the marine sponge Rhabdastrella globostellata

被引：34

作者：

Li, Jin ^{[1
]}

Xu, Bo ^{[1
]}

Cui, Jinrong ^{[1
]}

Deng, Zhiwei ^{[2
]}

de Voogd, Nicole J. ^{[3
]}

Proksch, Peter ^{[4
]}

Lin, Wenhan ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100075, Peoples R China

[3] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

[4] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 13期

关键词：

Marine sponge; Rhabdastrella globostellata; Globostelletins A-I; Anti-tumor cells; Targeting ubiqitin-proteasome system; Structure-activity relationship; STELLETTA-GLOBOSTELLATA; JASPIS-STELLIFERA; TRITERPENES; PROTEASOME; APOPTOSIS; NORTRITERPENOIDS; DEGRADATION; TENUIS; ARREST; CELLS;

D O I：

10.1016/j.bmc.2010.05.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine new isomalabaricane-derived natural products, globostelletins A-I (1-9), were isolated from the marine sponge Rhabdastrella globostellata, together with jaspolides F (10), rhabdastrellic acid-A (11), (-)-stellettin E (12), stellettins C (13) and D (14). The structures of these compounds were determined on the basis of extensive spectroscopic analyses and by comparison with the reported data in the literature. The inhibitory activities of compounds 1-12 against human tumor cell lines were evaluated, and their structure-activity relationships were discussed. In addition, rhabdastrellic acid-A (11) showed potent inhibition against HL-60 cells, and it induced the apoptosis of HL-60 cells in M/G2 phase. The mechanism of 11 targeting the ubiquitin-proteasome system, including the regulation of ChT-L and T-L target proteins is discussed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4639 / 4647

页数：9

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