Targeting the sticky fingers of HIV-1

被引：18

作者：

Blumenthal, Robert ^{[1
]}

Dimitrov, Dimiter S. ^{[1
]}

机构：

[1] NCI Frederick, Ctr Canc Res Nanobiol Program, NIH, Ft Detrick, MD 21702 USA

来源：

CELL | 2007年 / 129卷 / 02期

关键词：

D O I：

10.1016/j.cell.2007.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Winch et al. (2007) now identify a peptide corresponding to a portion of alpha 1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41.

引用

页码：243 / 245

页数：3

共 8 条

[1] Fusin - A place for HIV-1 and T4 cells to meet [J].

Dimitrov, DS .

NATURE MEDICINE, 1996, 2 (06) :640-641

[2] Virus entry: Molecular mechanisms and biomedical applications [J].

Dimitrov, DS .

NATURE REVIEWS MICROBIOLOGY, 2004, 2 (02) :109-122

[3] QUANTITATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION KINETICS [J].

DIMITROV, DS ;

WILLEY, RL ;

SATO, H ;

CHANG, LJ ;

BLUMENTHAL, R ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1993, 67 (04) :2182-2190

[4] The HIV Env-mediated fusion reaction [J].

Gallo, SA ;

Finnegan, CM ;

Viard, M ;

Raviv, Y ;

Dimitrov, A ;

Rawat, SS ;

Puri, A ;

Durell, S ;

Blumenthal, R .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1614 (01) :36-50

[5] Inhibition of HIV-1 envelope glycoprotein-mediated cell fusion by a DL-amino acid-containing fusion peptide - Possible recognition of the fusion complex [J].

Gerber, D ;

Pritsker, M ;

Gunther-Ausborn, S ;

Johnson, B ;

Blumenthal, R ;

Shai, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (46) :48224-48230

[6] HIV-1 INHIBITION BY A PEPTIDE [J].

JIANG, SB ;

LIN, K ;

STRICK, N ;

NEURATH, AR .

NATURE, 1993, 365 (6442) :113-113

[7] HIV entry inhibitors targeting gp41: From polypeptides to small-molecule compounds [J].

Liu, Shuwen ;

Wu, Shuguang ;

Jiang, Shibo .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (02) :143-162

[8] PEPTIDES CORRESPONDING TO A PREDICTIVE ALPHA-HELICAL DOMAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP41 ARE POTENT INHIBITORS OF VIRUS-INFECTION [J].

WILD, CT ;

SHUGARS, DC ;

GREENWELL, TK ;

MCDANAL, CB ;

MATTHEWS, TJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9770-9774

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