Micro-/nano-fluidic devices and in vivo fluorescence imaging based on quantum dots for cytologic diagnosis

被引：21
作者：
Luo, Minchuan [1 ]
Yukawa, Hiroshi [1 ,2 ,3 ,4 ,5 ]
Baba, Yoshinobu [1 ,2 ,3 ]
机构：
[1] Nagoya Univ, Grad Sch Engn, Dept Biomol Engn, Nanobio Analyt Chem,Biomol Chem,Chikusa Ku, Nagoya, Aichi 4648603, Japan
[2] Nagoya Univ, Inst Nano Life Syst, Inst Innovat Future Soc, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648603, Japan
[3] Natl Inst Quantum Sci & Technol, Inst Quantum Life Sci, Quantum Life & Med Sci Directorate, Inage Ku, Chiba 2638555, Japan
[4] Nagoya Univ, Inst Adv Res, Adv Analyt & Diagnost Imaging Ctr AADIC, Med Engn Unit MEU,Unit B3,Showa Ku, Tsurumai 65, Nagoya, Aichi 4668550, Japan
[5] Nagoya Univ, Dev Quantum Nano Canc Photoimmunotherapy Clin App, Showa Ku, Tsurumai 65, Nagoya, Aichi 4668550, Japan
来源：
LAB ON A CHIP | 2022年 / 22卷 / 12期
关键词：
MESENCHYMAL STEM-CELLS; HIGHLY LUMINESCENT; MICROFLUIDIC DEVICE; SENSITIVE DETECTION; PAPER; NANOCRYSTALS; CHEMILUMINESCENCE; VISUALIZATION; INTEGRATION; FABRICATION;
D O I：
10.1039/d2lc00113f
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Semiconductor quantum dots (QDs) possess attractive merits over traditional organic dyes, such as tunable emission, narrow emission spectra and good resistance against optical bleaching, and play a vital role in biosensing and bioimaging for cytologic diagnoses. Microfluidic technology is a potentially useful strategy, as it provides a rapid platform for tracing of disease markers. In vivo fluorescence imaging (FI) based on QDs has become popular for the analysis of complex biological processes. We herein report the applications of multifunctional fluorescent QDs as sensitive probes for diagnoses on cancer medicine and stem cell therapy via microfluidic chips and in vivo imaging.
引用
收藏
页码：2223 / 2236
页数：15
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