Plasmablastic lymphoma of the oral cavity: A review

被引：28

作者：

Sarode, Sachin C. ^{[1
]}

Sarode, Gargi S. ^{[1
]}

Patil, Anuprita ^{[1
]}

机构：

[1] Dr DY Patil Dent Coll & Hosp, Dept Oral Pathol & Microbiol, Pune 18, Maharashtra, India

来源：

ORAL ONCOLOGY | 2010年 / 46卷 / 03期

关键词：

Plasmablastic lymphoma; Non-Hodgkin's lymphoma; Diffuse large B-cell lymphoma; AIDS associated lymphoma; Oral cavity; HIV; CD138; EBV; HIV-NEGATIVE PATIENT; EPSTEIN-BARR-VIRUS; B-CELL LYMPHOMAS; EXPRESSION; DISEASE; CD79A; FEATURES; MYELOMA; VARIANT; ENTITY;

D O I：

10.1016/j.oraloncology.2009.12.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Plasmablastic lymphoma (PBL) is a rare AIDS associated non-Hodgkin's lymphoma (NHL), with predilection for the mucosa of oral cavity. It usually has a plasmablastic morphology, expressing plasma cell-associated antigens with weak or no expression of B-cell associated markers. The tumor cells also show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of Ig light chain (IgL) gene expression in most of the cases. An etiological role for EBV seems likely but the association with HHV8 is questionable. The treatment guidelines for PBL are not well defined and patients have been treated heterogeneously with chemo and/or radiotherapy, although the prognosis is poor. The present article discusses the 68 cases reported in English medical literature with comprehensive review on PBL involving the oral cavity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：146 / 153

页数：8

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