Aging and disease: connections to sirtuins

被引：267

作者：

Donmez, Gizem

Guarente, Leonard ^{[1
]}

机构：

[1] MIT, Paul F Glenn Lab, Cambridge, MA 02139 USA

来源：

AGING CELL | 2010年 / 9卷 / 02期

关键词：

aging; disease; sirtuin; SMALL-MOLECULE ACTIVATORS; SIRT1-NULL MICE DEVELOP; CALORIE RESTRICTION; LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; METABOLIC DISEASE; GENE-EXPRESSION; COLON-CANCER; RESVERATROL; DEACETYLASE;

D O I：

10.1111/j.1474-9726.2010.00548.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The sirtuins are highly conserved NAD-dependent deacetylases that were shown to regulate lifespan in lower organisms and affect diseases of aging in mammals, such as diabetes, cancer, and inflammation. Most relevant to the amelioration of disease, the SIR2 ortholog SIRT1 has been shown to deacetylate many important transcription factors to exert an overarching influence on numerous metabolic pathways. Here we discuss several diseases of aging for which SIRT1 has been recently shown to confer protection. These findings suggest that manipulating sirtuin activity pharmacologically may be a fruitful area to improve human health.

引用

页码：285 / 290

页数：6

共 50 条

[1] Motif module map reveals enforcement of aging by continual NF-κB activity [J].

Adler, Adam S. ;

Sinha, Saurabh ;

Kawahara, Tiara L. A. ;

Zhang, Jennifer Y. ;

Segal, Eran ;

Chang, Howard Y. .

GENES & DEVELOPMENT, 2007, 21 (24) :3244-3257

[2] Sirt1 regulates aging and resistance to oxidative stress in the heart [J].

Alcendor, Ralph R. ;

Gao, Shumin ;

Zhai, Peiyong ;

Zablocki, Daniela ;

Holle, Eric ;

Yu, Xianzhong ;

Tian, Bin ;

Wagner, Thomas ;

Vatner, Stephen F. ;

Sadoshima, Junichi .

CIRCULATION RESEARCH, 2007, 100 (10) :1512-1521

[3] IKK-β links inflammation to obesity-induced insulin resistance [J].

Arkan, MC ;

Hevener, AL ;

Greten, FR ;

Maeda, S ;

Li, ZW ;

Long, JM ;

Wynshaw-Boris, A ;

Poli, G ;

Olefsky, J ;

Karin, M .

NATURE MEDICINE, 2005, 11 (02) :191-198

[4] SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].

Banks, Alexander S. ;

Kon, Ning ;

Knight, Colette ;

Matsumoto, Michihiro ;

Gutierrez-Juarez, Roger ;

Rossetti, Luciano ;

Gu, Wei ;

Accili, Domenico .

CELL METABOLISM, 2008, 8 (04) :333-341

[5] A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice [J].

Barger, Jamie L. ;

Kayo, Tsuyoshi ;

Vann, James M. ;

Arias, Edward B. ;

Wang, Jelai ;

Hacker, Timothy A. ;

Wang, Ying ;

Raederstorff, Daniel ;

Morrow, Jason D. ;

Leeuwenburgh, Christiaan ;

Allison, David B. ;

Saupe, Kurt W. ;

Cartee, Gregory D. ;

Weindruch, Richard ;

Prolla, Tomas A. .

PLOS ONE, 2008, 3 (06)

[6] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[7] SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol [J].

Boily, G. ;

He, X. H. ;

Pearce, B. ;

Jardine, K. ;

McBurney, M. W. .

ONCOGENE, 2009, 28 (32) :2882-2893

[8] SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice [J].

Boily, Gino ;

Seifert, Erin L. ;

Bevilacqua, Lisa ;

He, Xiao Hong ;

Sabourin, Guillaume ;

Estey, Carmen ;

Moffat, Cynthia ;

Crawford, Sean ;

Saliba, Sarah ;

Jardine, Karen ;

Xuan, Jian ;

Evans, Meredith ;

Harper, Mary-Ellen ;

McBurney, Michael W. .

PLOS ONE, 2008, 3 (03)

[9] SIRT1 transgenic mice show phenotypes resembling calorie restriction [J].

Bordone, Laura ;

Cohen, Dena ;

Robinson, Ashley ;

Motta, Maria Carla ;

van Veen, Ed ;

Czopik, Agnieszka ;

Steele, Andrew D. ;

Crowe, Hayley ;

Marmor, Stephen ;

Luo, Jianyuan ;

Gu, Wei ;

Guarente, Leonard .

AGING CELL, 2007, 6 (06) :759-767

[10] IKKβ/NF-κB activation causes severe muscle wasting in mice [J].

Cai, DS ;

Frantz, JD ;

Tawa, NE ;

Melendez, PA ;

Oh, BC ;

Lidov, HGW ;

Hasselgren, PO ;

Frontera, WR ;

Lee, J ;

Glass, DJ ;

Shoelson, SE .

CELL, 2004, 119 (02) :285-298

← 1 2 3 4 5 →