LEISHMANICIDAL ACTIVITY OF Echinaster (Othilia) echinophorus CRUDE EXTRACT

被引：6

作者：

Garcia Parra, Marley ^{[1
]}

Monzote Fidalgo, Lianet ^{[1
]}

Mendiola Martinez, Judith ^{[1
]}

Montalvo Alvarez, Ana Margarita ^{[1
]}

Valdes Iglesias, Olga ^{[2
]}

机构：

[1] Inst Med Trop Pedro Kourf, Dept Parasitol, Havana, Cuba

[2] Ctr Bioprod Marinos, Havana, Cuba

来源：

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2010年 / 52卷 / 02期

关键词：

Leishmania amazonensis; Echinaster (Othilia) echinophorus; Antiprotozoal activity; Saponins; ANTILEISHMANIAL ACTIVITY; IN-VITRO; CUTANEOUS LEISHMANIASIS; SAPONIN; SPONGE; EFFICACY;

D O I：

10.1590/S0036-46652010000200005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 mu g.mL(-1) respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.

引用

页码：89 / 93

页数：5

共 35 条

[1] Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases [J].

Al-Abdely, HM ;

Graybill, JR ;

Loebenberg, D ;

Melby, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (12) :2910-2914

[2] DRUG CYTOTOXICITY ASSAY FOR AFRICAN TRYPANOSOMES AND LEISHMANIA SPECIES [J].

BODLEY, AL ;

MCGARRY, MW ;

SHAPIRO, TA .

JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (04) :1157-1159

[3] CULTURE MICROTITRATION - A SENSITIVE METHOD FOR QUANTIFYING LEISHMANIA-INFANTUM IN TISSUES OF INFECTED MICE [J].

BUFFET, PA ;

SULAHIAN, A ;

GARIN, YJF ;

NASSAR, N ;

DEROUIN, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (09) :2167-2168

[4] Variation of leishmanicidal activity in four populations of Urechites andrieuxii [J].

Chan-Bacab, MJ ;

Balanza, E ;

Deharo, E ;

Muñoz, V ;

García, RD ;

Peña-Rodríguez, LM .

JOURNAL OF ETHNOPHARMACOLOGY, 2003, 86 (2-3) :243-247

[5] Drug discovery from natural sources [J].

Chin, Young-Won ;

Balunas, Marcy J. ;

Chai, Hee Byung ;

Kinghorn, A. Douglas .

AAPS JOURNAL, 2006, 8 (02) :E239-E253

[6] Anti-infective potential of natural products: How to develop a stronger in vitro 'proof-of-concept' [J].

Cos, Paul ;

Vlietinck, Arnold J. ;

Vanden Berghe, Dirk ;

Maes, Louis .

JOURNAL OF ETHNOPHARMACOLOGY, 2006, 106 (03) :290-302

[7] Chemotherapy of leishmaniasis [J].

Croft, SL ;

Yardley, V .

CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (04) :319-342

[8]

CUELLAR A, 2001, FARMACOGNOSIA PRODUC, P25

[9] Antileishmanial activity of an indole alkaloid from Peschiera australis [J].

Delorenzi, JC ;

Attias, M ;

Gattass, CR ;

Andrade, M ;

Rezende, C ;

Pinto, AD ;

Henriques, AT ;

Bou-Habib, DC ;

Saraiva, EMB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (05) :1349-1354

[10] Leishmaniasis: current situation and new perspectives [J].

Desjeux, P .

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2004, 27 (05) :305-318

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