Optical Microangiography and Progressive Ganglion Cell-Inner Plexiform Layer Loss in Primary Open-Angle Glaucoma

PURPOSE: To evaluate the association between optical microangiography (OMAG) measurements and progres-sive ganglion cell-inner plexiform layer (GCIPL) loss in patients with primary open-angle glaucoma (POAG). DESIGN: Prospective case series. METHODS: Sixty-three eyes of 38 patients with POAG were studied for >= 2 years and with >= 3 optical coher-ence tomography examinations. Only those hemifields with mild to moderate functional damage at baseline (106 hemifields) were included in the analysis. OMAG imaging was performed at the baseline visit. The effects of clin-ical parameters (age, gender, central corneal thickness, presence of disc hemorrhage, and mean and fluctuation of intraocular pressure), baseline mean deviation, reti-nal nerve fiber layer, and GCIPL thickness and baseline OMAG measurements (peripapillary and macular perfu-sion density [PD] and vessel density [VD]) on the rate of change of GCIPL thickness were evaluated using linear mixed models. RESULTS: Average (+/- standard deviation) mean devia-tion, quadrant retinal nerve fiber layer, and sector GCIPL thickness of the analyzed hemifields respectively at base-line were -5.2 +/- 2.8 dB, 94.5 +/- 20.0 mu m, and 72.4 +/- 8.7 mu m, respectively. Peripapillary PD and VD in the quadrant were 43.1% +/- 7.0% and 17.0 +/- 2.6 mm/mm2, respectively. Macular PD and VD in the quadrant were 37.2% +/- 6.9% and 15.1 +/- 2.6 mm/mm(2), respectively. Rate of sector GCIPL change was -0.97 +/- 0.15 mu m per year. Multivariate mixed models showed that lower peri-papillary PD (coefficient 0.04, P = .01) and VD (coeffi-cient 0.09, P = .05) were significantly associated with a faster rate of GCIPL loss. CONCLUSIONS: Lower baseline peripapillary OMAG measurements were significantly associated with a faster rate of GCIPL loss in patients with mild to moderate POAG. (c) 2021 Elsevier Inc. All rights reserved.