A review on biomass-derived levulinic acid for application in drug synthesis

被引:20
作者
Zhang, Mingyue [1 ,2 ]
Wang, Nan [1 ,3 ]
Liu, Jianguo [1 ,2 ]
Wang, Chenguang [1 ,2 ]
Xu, Ying [1 ,2 ]
Ma, Longlong [1 ,2 ]
机构
[1] Chinese Acad Sci, Guangzhou Inst Energy Convers, Key Lab Renewable Energy, Guangzhou 510640, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Tianjin Univ, Sch Environm Sci & Engn, Tianjin, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
Biomass; levulinic acid; drug; linkers; medicinal materials; reducing cost; ONE-POT SYNTHESIS; 5-AMINOLEVULINIC ACID; BIOLOGICAL EVALUATION; DERIVATIVES; DELIVERY; POLYMER; DESIGN; NANOPARTICLES; INHIBITORS; DOCETAXEL;
D O I
10.1080/07388551.2021.1939261
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Levulinic acid (LEV) has been identified as a key building block chemical produced entirely from biomass. Its derivatives can be used to synthesize a variety of value-added chemicals, such as 2-butanone, 2-methyltetrahydrofuran, and so on. LEV has carbonyl and carboxyl functional groups, which makes it flexible, diverse, and unique during drug synthesis. It also reduces the cost of drug synthesis and makes the reaction cleaner and, not the least, has untapped potential in the field of medicine. This article reviews the application of LEV in cancer treatment, medical materials, and other medical fields. Overall, LEV can be used in the following ways: (1) Used as a raw material to directly synthesize drugs; (2) Used to synthesize related derivatives, which can be more specifically used in drug synthesis, and derivatives can achieve the corresponding release of drugs, such as paclitaxel (PTX)- LEV, polymer-betulinic acid (BA)-LEV after amidation; (3) It can modify chemical reagents or act as linkers to connect pharmaceutical reagents with carriers to form pharmaceutical intermediates, a pharmaceutical intermediate skeleton, and so on. (4) It can acylate and esterify to form: acetylpropionate and levulinyl, the indole, pyridazine, and other medicinally active functional groups can be synthesized by a long chain, which can reduce the cost of drug synthesis and simplify the tedious synthesis steps. (5) To form the protective group of levulinic acid, the hydroxyl or carboxyl position is first protected, and then the protective group is removed after the corresponding reaction, in order to participate in drug synthesis.
引用
收藏
页码:220 / 253
页数:34
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