Understanding eukaryotic chemotaxis: a pseudopod-centred view

被引：112

作者：

Insall, Robert H. ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 06期

基金：

英国医学研究理事会;

关键词：

PROTEIN BETA-SUBUNIT; CELL-MOVEMENT; DICTYOSTELIUM CHEMOTAXIS; SHALLOW GRADIENTS; LEADING-EDGE; ACTIN; SHAPE; MOTILITY; SIGNALS; ABSENCE;

D O I：

10.1038/nrm2905

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.

引用

页码：453 / 458

页数：6

共 52 条

[21] PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP [J].

Heit, Bryan ;

Liu, Lixin ;

Colarusso, Pina ;

Puri, Kamal D. ;

Kubes, Paul .

JOURNAL OF CELL SCIENCE, 2008, 121 (02) :205-214

[22] Chemotaxis in the absence of PIP3 gradients [J].

Hoeller, Oliver ;

Kay, Robert R. .

CURRENT BIOLOGY, 2007, 17 (09) :813-817

[23] Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways [J].

Ibarra, N ;

Blagg, SL ;

Vazquez, F ;

Insall, RH .

CURRENT BIOLOGY, 2006, 16 (07) :717-722

[24] Tumor suppressor PTEN mediates sensing of chemoattractant gradients [J].

Iijima, M ;

Devreotes, P .

CELL, 2002, 109 (05) :599-610

[25] PIP3, PIP2, and cell movement - Similar messages, different meanings? [J].

Insall, RH ;

Weiner, OD .

DEVELOPMENTAL CELL, 2001, 1 (06) :743-747

[26]

KILLICH T, 1993, J CELL SCI, V106, P1005

[27] CELL-MOVEMENT AND SHAPE ARE NONRANDOM AND DETERMINED BY INTRACELLULAR, OSCILLATORY ROTATING WAVES IN DICTYOSTELIUM AMEBAS [J].

KILLICH, T ;

PLATH, PJ ;

HASS, EC ;

XIANG, W ;

BULTMANN, H ;

RENSING, L ;

VICKER, MG .

BIOSYSTEMS, 1994, 33 (02) :75-87

[28] Isolation, spreading, locomotion on various substrata, and the effect of hypotonicity on locomotion of fish keratinocytes [J].

Korohoda, W ;

Drukala, J ;

Sroka, J ;

Madeja, Z .

BIOCHEMISTRY AND CELL BIOLOGY, 1997, 75 (03) :277-286

[29] Exocyst is involved in polarized cell migration and cerebral cortical development [J].

Letinic, Kresimir ;

Sebastian, Rafael ;

Toomre, Derek ;

Rakic, Pasko .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (27) :11342-11347

[30] Persistent Cell Motion in the Absence of External Signals: A Search Strategy for Eukaryotic Cells [J].

Li, Liang ;

Norrelykke, Simon F. ;

Cox, Edward C. .

PLOS ONE, 2008, 3 (05)

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