The Role of Ghrelin in Anorexia Nervosa

被引：46

作者：

Schalla, Martha A. ^{[1
,2
,3
,4
]}

Stengel, Andreas ^{[1
,2
,3
,4
,5
]}

机构：

[1] Charite, Dept Psychosomat Med, Charite Ctr Internal Med & Dermatol, D-12203 Berlin, Germany

[2] Free Univ Berlin, D-12203 Berlin, Germany

[3] Humboldt Univ, D-12203 Berlin, Germany

[4] Berlin Inst Hlth, D-12203 Berlin, Germany

[5] Med Univ Hosp Tubingen, Dept Psychosomat Med & Psychotherapy, D-72076 Tubingen, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期

关键词：

animal model; body weight; brain-gut axis; drug; eating disorder; food intake; gut-brain axis; hormone; hunger; metabolism; psychosomatic; satiety; DES-ACYL GHRELIN; O-ACYLTRANSFERASE GOAT; GLUCOSE-TOLERANCE TEST; HORMONE SECRETAGOGUE RECEPTOR; FAMILY TRIOS ANALYSIS; BODY-MASS-INDEX; GROWTH-FACTOR-I; PLASMA GHRELIN; RESTRICTING-TYPE; CIRCULATING GHRELIN;

D O I：

10.3390/ijms19072117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the stomach, is the only known peripherally produced and centrally acting peptide that stimulates food intake and therefore attracted a lot of attention with one major focus on the treatment of conditions where an increased energy intake or body weight gain is desired. Anorexia nervosa is an eating disorder characterized by a pronounced reduction of body weight, a disturbed body image and hormonal alterations. Ghrelin signaling has been thoroughly investigated under conditions of anorexia nervosa. The present review will highlight these alterations of ghrelin in anorexia and discuss possible treatment strategies targeting ghrelin signaling. Lastly, gaps in knowledge will be mentioned to foster future research.

引用

页数：16

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