Systemic Immune-Inflammatory Index Predicts Clinical Outcomes for Elderly Patients with Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention

被引:99
作者
Huang, Jiabao [1 ]
Zhang, Qing [1 ]
Wang, Runchang [1 ]
Ji, Hongyan [1 ]
Chen, Yusi [1 ]
Quan, Xiaoqing [2 ]
Zhang, Cuntai [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[2] Shenzhen Longhua Dist Cent Hosp, Dept Gen Practice, Shenzhen, Guangdong, Peoples R China
来源
MEDICAL SCIENCE MONITOR | 2019年 / 25卷
关键词
Inflammation; Myocardial Infarction; Prognosis; Systemic Immune-Inflammatory Index; RELATIVE LYMPHOCYTE COUNT; IN-HOSPITAL MORTALITY; BLOOD-CELL SUBTYPES; RISK STRATIFICATION; HEART-FAILURE; ASSOCIATION; DISEASE; PROGNOSIS; RATIO; NEUTROPHIL;
D O I
10.12659/MSM.919802
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: We assessed the utility of the systemic immune-inflammatory index (SII) in estimating the in-hospital and long- term prognosis of elderly patients with acute myocardial infarction (AMI) who received percutaneous coronary intervention (PCI). Material/Methods: Our study evaluated 711 consecutive elderly patients (age 65-85 years) from January 2015 to December 2017. The correlation between clinical outcomes and SII was analyzed through the stepwise Cox regression analysis and the Kaplan-Meier approach. The clinical endpoints were all-cause mortality and major adverse cardiovascular and cerebrovascular events (MACCE) in-hospital and during 3-year follow-up. Results: The study enrolled 711 elderly patients with AMI (66.95% male, 71.99 +/- 0.19 years). Kaplan-Meier analysis showed a lower survival rate in patients with higher SII scores, which also predicted in-hospital and long-term (<= 3 years) outcomes. In multivariate analyses, SII showed an independent predictive value for in-hospital mortality (hazard ratio (FIR), 3.32; 95% confidence interval (CI), 1.55-7.10; p<0.01), in-hospital MACCE (HR, 1.43; 95%CI, 1.02-2.00; p=0.04), long-term mortality (HR, 1.95; 95%CI, 1.23-3.09; p<0.01), along with long-term MACCE (HR, 1.72; 95%CI, 1.23-2.40; p<0.01). Moreover, SII showed a weak but significant positive relationship with the Gensini score among patients developing non-ST-segment elevation myocardial infarction (r=0.18; p<0.01). Conclusions: SII, a readily available laboratory marker, is a potential indicator to predict the clinical endpoints for elderly patients with AMI undergoing PCI.
引用
收藏
页码:9690 / 9701
页数:12
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