A multicenter longitudinal study of the prevalence and mortality rate of systemic lupus erythematosus patients in Oman: Oman Lupus Study

被引:8
作者
Al-Adhoubi, Nasra K. [1 ,2 ]
Al-Balushi, Farida [1 ]
Al Salmi, Issa [2 ,3 ]
Ali, Maha [4 ]
Al Lawati, Talal [5 ]
Al Lawati, Batool S. H. [5 ]
Abdwani, Reem [6 ]
Al Shamsi, Ali [7 ]
Al Kaabi, Juma [7 ]
Al Mashaani, Musallam [8 ]
Krishna Jha, Divij [1 ]
Sayed, Sherin [1 ]
Al-Araimi, Tariq [1 ]
Liyanage, Prabha [1 ]
Al Shirawi, Ali [5 ]
Al Wahshi, Humaid A. [1 ]
机构
[1] Royal Hosp, Rheumatol Unit, Muscat, Oman
[2] Oman Med Specialty Board, Internal Med, Muscat, Oman
[3] Royal Hosp, Nephrol Dept, Muscat, Oman
[4] Al Nahdha Hosp, Rheumatol Unit, Muscat, Oman
[5] Sultan Qaboos Univ Hosp, Adult Rheumatol Unit, Muscat, Oman
[6] Sultan Qaboos Univ Hosp, Paediat Rheumatol Unit, Muscat, Oman
[7] Al Buraimi Hosp, Rheumatol Unit, Al Buraimi, Oman
[8] Sultan Qaboos Hosp, Rheumatol Unit, Salalah, Oman
关键词
clinical aspects; epidemiology; systemic lupus erythematosus; IMMUNOLOGICAL MANIFESTATIONS; SLE PATIENTS; CLASSIFICATION; EPIDEMIOLOGY; CRITERIA;
D O I
10.1111/1756-185X.14130
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim This study is a longitudinal multicenter study which aims to find the prevalence, the demographic data, survival and mortality rates of patients with systemic lupus erythematosus (SLE) in Oman. Method All Omani patients, pediatrics and adults diagnosed with SLE, who fulfill either the 1997 American College of Rheumatology or Systemic Lupus International Collaborating Clinics classifications criteria for SLE were included from January 2006 till February 2020. Results In total 1160 patients were included in this cohort. Data analysis showed that patient's ages ranged from 2-82 years with female predominance and female-to-male ratio of 7:1 (87.7% female,12.3% male). The mean prevalence of SLE among different age groups was 38.8 (range 5-63 per 100 000 inhabitants). The mortality rate was found to be 5%. Male patients had significantly higher mortality rate than females (7.6% vs 5.4%, P value = .04). Sepsis was the commonest cause of mortality (34%). The coexistence of systemic sclerosis correlates significantly with death (P = .002). Survival analysis in our data showed 5, 10, 20, 40-year survival rates of 100%, 100%, 99% and 90% respectively for antinuclear antibody (ANA) positive patients and lower survival rate for ANA negative patients with 5,10, 20, 40-year survival rates of 100, 99%, 99% and 75%, respectively. Conclusion This study showed that the mean prevalence of SLE in Oman to be 38.8 (range 5-63) per 100 000 inhabitants. The 40-year survival rate among patients with positive ANA was found to be 90%, while patients with negative ANA had worse survival outcomes.
引用
收藏
页码:847 / 854
页数:8
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