Oseltamivir-Resistant Influenza Viruses A (H1N1) during 2007-2009 Influenza Seasons, Japan

被引：40

作者：

Ujike, Makoto

Shimabukuro, Kozue

Mochizuki, Kiku

Obuchi, Masatsugu

Kageyama, Tsutomu

Shirakura, Masayuki

Kishida, Noriko

Yamashita, Kazuyo

Horikawa, Hiroshi ^{[2
]}

Kato, Yumiko ^{[2
]}

Fujita, Nobuyuki ^{[2
]}

Tashiro, Masato

Odagiri, Takato ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo 2080011, Japan

[2] Natl Inst Technol & Evaluat, Tokyo, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 06期

关键词：

NEURAMINIDASE INHIBITOR RESISTANCE; IN-VITRO; A(H1N1); SURVEILLANCE; TRANSMISSION; AMANTADINE; MUTATION; ORIGINS; HUMANS;

D O I：

10.3201/eid1606.091623

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To monitor oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y in neuraminidase (NA) in Japan during 2 influenza seasons, we analyzed 3,216 clinical samples by NA sequencing and/or NA inhibition assay. The total frequency of ORVs was 2.6% (45/1,734) during the 2007-08 season and 99.7% (1,477/1,482) during the 2008-09 season, indicating a marked increase in ORVs in Japan during 1 influenza season. The NA gene of ORVs in the 2007-08 season fell into 2 distinct lineages by D354G substitution, whereas that of ORVs in the 2008-09 season fell into 1 lineage. NA inhibition assay and M2 sequencing showed that almost all the ORVs were sensitive to zanamivir and amantadine. The hemagglutination inhibition test showed that ORVs were antigenetically similar to the 2008 09 vaccine strain A/Brisbane/59/2007. Our data indicate that the current vaccine or zanamivir and amantadine are effective against recent ORVs, but continuous surveillance remains necessary.

引用

页码：926 / 935

页数：10

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