Chiral Centers in the side chains of α-amino acids control the helical screw sense of peptides

被引：65
|
作者：
Tanaka, M [1 ]
Demizu, Y
Doi, M
Kurihara, M
Suemune, H
机构：
[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan
[2] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan
[3] Natl Inst Hlth Sci, Div Organ Chem, Tokyo 1588501, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 40期
关键词：
amino acids; chirality; conformation analysis; helical structures; peptidomimetics;
D O I：
10.1002/anie.200460420
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chirality on the side suffices: The screw sense of 310- and α-helices formed by the oligopeptides 1, which have no α-carbon chiral centers, is controlled by the chiral centers in their side chains. These results imply that just the side chain chiral centers of isoleucine and threonine would affect the secondary structure of their oligopeptides.
引用
收藏
页码：5360 / 5363
页数：4
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