Fabrication of injectable and superelastic nanofiber rectangle matrices ("peanuts") and their potential applications in hemostasis

被引：106
作者：
Chen, Shixuan [1 ,2 ]
Carlson, Mark A. [3 ,4 ,5 ,6 ]
Zhang, Yu Shrike [7 ]
Hu, Yong [8 ]
Xie, Jingwei [1 ,2 ]
机构：
[1] Univ Nebraska Med Ctr, Dept Surg Transplant, Omaha, NE 68198 USA
[2] Univ Nebraska Med Ctr, Mary & Dick Holland Regenerat Med Program, Omaha, NE 68198 USA
[3] Univ Nebraska Med Ctr, Dept Surg Gen Surg & Genet, Omaha, NE 68198 USA
[4] Univ Nebraska Med Ctr, Dept Cell Biol, Omaha, NE 68198 USA
[5] Univ Nebraska Med Ctr, Dept Anat, Omaha, NE 68198 USA
[6] VA Nebraska Western Iowa Hlth Care Syst, Dept Surg, Omaha, NE 68105 USA
[7] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA
[8] Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210093, Jiangsu, Peoples R China
来源：
BIOMATERIALS | 2018年 / 179卷
基金：
美国国家卫生研究院;
关键词：
Electrospinning; Nanofiber rectangle matrix; Injectable; Superelastic; Hemostasis; COMBAT CASUALTY CARE; HEMORRHAGE; SCAFFOLDS; DRESSINGS; OCCLUSION; EFFICACY; DELIVERY; SUTURES; WOUNDS; MODEL;
D O I：
10.1016/j.biomaterials.2018.06.031
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Uncontrolled hemorrhage, which typically involves the torso and/or limb" junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix ("peanut") fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples. These nanofiber peanuts are capable of being packed into a syringe for injection. Further in vivo tests indicated the effectiveness of nanofiber peanuts for hemostasis in a porcine liver injury model. This new class of nanofiber-based materials may hold great promise for hemostatic applications. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：46 / 59
页数：14
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