Preparation of Chitosan microspheres containing 166Dy/166Ho in vivo generators and their theranostic potential

被引：1

作者：

Cho, Bo-Bae ^{[1
]}

Choi, Kanghyuk ^{[1
]}

机构：

[1] Korea Atom Energy Res Inst, 111 Daedeok Daero,989beon Gil, Daejeon 34057, South Korea

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2018年 / 317卷 / 02期

关键词：

Chitosan microspheres; In vivo generator; Dysprosium-166; Holmium-166; POLY(L-LACTIC ACID) MICROSPHERES; NEUTRON-ACTIVATION; HO-166; BIODISTRIBUTION; DYSPROSIUM; THERAPY; CARRIER; KR-81M;

D O I：

10.1007/s10967-018-5984-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chitosan microsphere (MS) loaded with Dy-166/Ho-166 were designed for therapy of unresectable liver tumor through an in vivo generator system. The mean size of the MS was affected by the stirring rate, concentration of emulsifier and cross-linking agent. The MS have ability to absorb water and ethanol to swell to eightfold their original volume. Importantly, approximately 53.89% +/- 2.44 of Dy-166 was absorbed into the MS to release in human serum about 8% of the absorbed amount. The advantages of high absorption and low release rate show these MS promising as a potential carrier of an in vivo generator system.

引用

页码：1123 / 1132

页数：10

共 32 条

[1] Search of ligands suitable for 212Pb/212Bi in vivo generators [J].

Bartos, Barbara ;

Lyczko, Krzysztof ;

Kasperek, Agata ;

Krajewski, Seweryn ;

Bilewicz, Aleksander .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2013, 295 (01) :205-209

[2]

Borchardt PE, 2003, CANCER RES, V63, P5084

[3]

Bruehlmeier M, 2000, J NUCL MED, V41, P781

[4]

Calonder C, 1999, J NEUROCHEM, V73, P2047

[5] SEPARATION OF CARRIER-FREE HO-166 FROM NEUTRON-IRRADIATED DYSPROSIUM TARGETS [J].

DADACHOVA, E ;

MIRZADEH, S ;

LAMBRECHT, RM ;

HETHERINGTON, EL ;

KNAPP, FF .

ANALYTICAL CHEMISTRY, 1994, 66 (23) :4272-4277

[6] In Vivo Radionuclide Generators for Diagnostics and Therapy [J].

Edem, Patricia E. ;

Fonslet, Jesper ;

Kjaer, Andreas ;

Herth, Matthias ;

Severin, Gregory .

BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2016, 2016

[7] [166Dy]Dy/166Ho hydroxide macro aggregates:: an in vivo generator system for radiation synovectomy [J].

Ferro-Flores, G ;

Hernández-Oviedo, O ;

de Murphy, CA ;

Tendilla, JI ;

Monroy-Guzmán, F ;

Pedraza-López, M ;

Aldama-Alvarado, K .

APPLIED RADIATION AND ISOTOPES, 2004, 61 (06) :1227-1233

[8] Development of [62Zn/62Cu]-DOTA-rituximab as a possible novel in vivo PET generator for anti-CD20 antigen imaging [J].

Gholipour, Nazila ;

Jalilian, Amir R. ;

Fazaeli, Yousef ;

Sabzevari, Omid ;

Moradkhani, Sedigheh ;

Bolourinovin, Fateme ;

Khalaj, Ali .

RADIOCHIMICA ACTA, 2014, 102 (11) :1035-1045

[9]

He Yuejun, 2005, Yingyong Shengtai Xuebao, V16, P1983

[10]

Henriksen G, 2002, CANCER RES, V62, P3120

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