SUCCESSFUL MOBILIZATION WITH AMD3100 AND FILGRASTIM WITH ENGRAFTMENT OF AUTOLOGOUS PERIPHERAL BLOOD STEM CELLS IN A HEAVILY PRETREATED PEDIATRIC PATIENT WITH RECURRENT BURKITT LYMPHOMA

被引：7

作者：

Flatt, Terrie ^{[1
]}

Lewing, Karen ^{[1
]}

Gonzalez, Celia ^{[1
]}

Anthony, Karen ^{[1
]}

Ryan, Robin ^{[1
]}

Jones, Ron ^{[1
]}

Gamis, Alan ^{[1
]}

Dalal, Jignesh ^{[1
]}

机构：

[1] Childrens Mercy Hosp, Dept Hematol Oncol, Kansas City, MO 64108 USA

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2010年 / 27卷 / 02期

关键词：

PLUS G-CSF; NON-HODGKINS-LYMPHOMA; BONE-MARROW-TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; RANDOMIZED-TRIAL; PROGENITOR CELLS; CD34(+) CELLS; CHILDREN; LEUKEMIA; RESCUE;

D O I：

10.3109/08880010903447367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors report a case of a 13-year-old female with recurrent Burkitt lymphoma who was heavily pretreated with chemotherapy. During chemotherapy for relapse, she developed serious aspergillus infection of the palate and sinuses. Despite 10 mu g/kg of filgrastim for 5 days, peripheral blood CD34<SU+</SU cells remained < 1/mu L. Hematopoietic progenitor cells were subsequently successfully mobilized with a combination of AMD3100 and filgrastim without tumor or fungus contamination. After transplantation, the patient achieved complete engraftment without exacerbation of fungal infection. This is the first case report of a pediatric patient with relapsed Burkitt lymphoma with mobilization of hematopoietic progenitor cells by AMD3100 without any adverse reactions.</.

引用

页码：138 / 149

页数：12

共 35 条

[11] Plasma levels of SDF-1 and expression of SDF-1 receptor on CD34+ cells in mobilized peripheral blood of non-Hodgkin's lymphoma patients [J].

Gazitt, Y ;

Liu, Q .

STEM CELLS, 2001, 19 (01) :37-45

[12] A Study of Rituximab and Ifosfamide, Carboplatin, and Etoposide Chemotherapy in Children with Recurrent/Refractory B-Cell (CD20+) Non-Hodgkin Lymphoma and Mature B-Cell Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group [J].

Griffin, Timothy C. ;

Weitzman, Sheila ;

Weinstein, Howard ;

Chang, Myron ;

Cairo, Mitchell ;

Hutchison, Robert ;

Shiramizu, Bruce ;

Wiley, Joseph ;

Woods, Deborah ;

Barnich, Margaret ;

Gross, Thomas G. .

PEDIATRIC BLOOD & CANCER, 2009, 52 (02) :177-181

[13]

Halle P, 2000, Pediatr Transplant, V4, P285, DOI 10.1034/j.1399-3046.2000.00128.x

[14] Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers [J].

Hendrix, CW ;

Flexner, C ;

MacFarland, RT ;

Giandomenico, C ;

Fuchs, EJ ;

Redpath, E ;

Bridger, G ;

Henson, GW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1667-1673

[15] Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection [J].

Hendrix, CW ;

Collier, AC ;

Lederman, MM ;

Schols, D ;

Pollard, RB ;

Brown, S ;

Jackson, JB ;

Coombs, RW ;

Gleshy, MJ ;

Flexner, CW ;

Bridger, GJ ;

Badel, K ;

MacFarland, RT ;

Henson, GW ;

Calandra, G .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2004, 37 (02) :1253-1262

[16] Outcomes of treatment of children and adolescents with recurrent non-Hodgkin's lymphoma and Hodgkin's disease with dexamethasone, etoposide, cisplatin, cytarabine, and L-asparaginase, maintenance chemotherapy, and transplantation: Children's Cancer Group study CCG-5912 [J].

Kobrinsky, NL ;

Sposto, R ;

Shah, NR ;

Anderson, JR ;

DeLaat, C ;

Morse, M ;

Warkentin, P ;

Gilchrist, GS ;

Cohen, MD ;

Shina, D ;

Meadows, AT .

JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (09) :2390-2396

[17]

KORBLING M, 1994, BLOOD STEM CELL TRAN, P9

[18] Predictors of therapy-related leukemia and myelodysplasia following autologous transplantation for lymphoma: an assessment of risk factors [J].

Krishnan, A ;

Bhatia, S ;

Slovak, ML ;

Arber, DA ;

Niland, JC ;

Nademanee, A ;

Fung, H ;

Bhatia, R ;

Kashyap, A ;

Molina, A ;

O'Donnell, MR ;

Parker, PA ;

Sniecinski, I ;

Snyder, DS ;

Spielberger, R ;

Stein, A ;

Forman, SJ .

BLOOD, 2000, 95 (05) :1588-1593

[19] High-dose chemotherapy with autologous bone marrow rescue in children with poor-risk Burkitt's lymphoma: A report from the European Lymphoma Bone Marrow Transplantation Registry [J].

Ladenstein, R ;

Pearce, R ;

Hartmann, O ;

Patte, C ;

Goldstone, T ;

Philip, T .

BLOOD, 1997, 90 (08) :2921-2930

[20]

Lefrère F, 2004, HAEMATOLOGICA, V89, P1532

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