SUCCESSFUL MOBILIZATION WITH AMD3100 AND FILGRASTIM WITH ENGRAFTMENT OF AUTOLOGOUS PERIPHERAL BLOOD STEM CELLS IN A HEAVILY PRETREATED PEDIATRIC PATIENT WITH RECURRENT BURKITT LYMPHOMA

被引：7

作者：

Flatt, Terrie ^{[1
]}

Lewing, Karen ^{[1
]}

Gonzalez, Celia ^{[1
]}

Anthony, Karen ^{[1
]}

Ryan, Robin ^{[1
]}

Jones, Ron ^{[1
]}

Gamis, Alan ^{[1
]}

Dalal, Jignesh ^{[1
]}

机构：

[1] Childrens Mercy Hosp, Dept Hematol Oncol, Kansas City, MO 64108 USA

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2010年 / 27卷 / 02期

关键词：

PLUS G-CSF; NON-HODGKINS-LYMPHOMA; BONE-MARROW-TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; RANDOMIZED-TRIAL; PROGENITOR CELLS; CD34(+) CELLS; CHILDREN; LEUKEMIA; RESCUE;

D O I：

10.3109/08880010903447367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors report a case of a 13-year-old female with recurrent Burkitt lymphoma who was heavily pretreated with chemotherapy. During chemotherapy for relapse, she developed serious aspergillus infection of the palate and sinuses. Despite 10 mu g/kg of filgrastim for 5 days, peripheral blood CD34<SU+</SU cells remained < 1/mu L. Hematopoietic progenitor cells were subsequently successfully mobilized with a combination of AMD3100 and filgrastim without tumor or fungus contamination. After transplantation, the patient achieved complete engraftment without exacerbation of fungal infection. This is the first case report of a pediatric patient with relapsed Burkitt lymphoma with mobilization of hematopoietic progenitor cells by AMD3100 without any adverse reactions.</.

引用

页码：138 / 149

页数：12

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