Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan

被引：6

作者：

Conejo-Cuevas, Guillermo ^{[1
]}

Ruiz-Rubio, Leire ^{[1
,2
]}

Saez-Martinez, Virginia ^{[3
]}

Perez-Gonzalez, Raul ^{[3
]}

Gartziandia, Oihane ^{[3
]}

Huguet-Casquero, Amaia ^{[3
]}

Perez-Alvarez, Leyre ^{[1
,2
]}

机构：

[1] Univ Basque Country, Fac Sci & Technol, Dept Phys Chem, Macromol Chem Grp LABQUIMAC,UPV EHU, Barrio Sarriena S-N, Leioa 48940, Spain

[2] Basque Ctr Mat Applicat & Nanostruct, BCMat, UPV EHU Sci Pk, Leioa 48940, Spain

[3] I Med S Coop Parque Tecnol Alava, Albert Einstein 15,Nave 15, Vitoria 01510, Spain

来源：

POLYMERS | 2022年 / 14卷 / 06期

关键词：

hyaluronic acid; chitosan; catechol; tissue adhesive; CROSS-LINKING; DRUG-DELIVERY; HYDROGELS; MUCOADHESION;

D O I：

10.3390/polym14061209

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Spontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. Highly valuable properties such as low viscosity before external application, adequate filmogenic capacity, rapid gelation and tissue adhesion are required in order to use them for those therapeutic applications. In addition, biocompatibility and biodegradability are also mandatory. Accordingly, biopolymers, such as hyaluronic acid (HA) and chitosan (CHI), that have shown great potential for wound healing applications are excellent candidates due to their unique physiochemical and biological properties, such as moisturizing and antimicrobial ability, respectively. In this study, both biopolymers were modified by covalent anchoring of catechol groups, and the obtained hydrogels were characterized by studying, in particular, their tissue adhesiveness and film forming capacity for potential skin wound healing applications. Tissue adhesiveness was related to o-quinone formation over time and monitored by visible spectroscopy. Consequently, an opposite effect was observed for both polysaccharides. As gelation advances for HA-CA, it becomes more adhesive, while competitive reactions of quinone in CHI-CA slow down tissue adhesiveness and induce a detriment of the filmogenic properties.

引用

页数：16

共 32 条

[1] Bioactive and adhesive properties of multilayered coatings based on catechol-functionalized chitosan/hyaluronic acid and bioactive glass nanoparticles [J].