Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial

被引：49

作者：

Sanchez-Rodriguez, Estefania ^{[1
]}

Lima-Cabello, Elena ^{[2
]}

Biel-Glesson, Sara ^{[3
]}

Fernandez-Navarro, Jose R. ^{[3
]}

Calleja, Miguel A. ^{[3
]}

Roca, Maria ^{[4
]}

Espejo-Calvo, Juan A. ^{[5
]}

Gil-Extremera, Blas ^{[6
]}

Soria-Florido, Maria ^{[7
]}

de la Torre, Rafael ^{[8
]}

Fito, Montserrat ^{[7
,9
]}

Covas, Maria-Isabel ^{[9
,10
,11
]}

de Dios Alche, Juan ^{[2
]}

Martinez de Victoria, Emilio ^{[12
]}

Gil, Angel ^{[1
,9
]}

Mesa, Maria D. ^{[1
]}

机构：

[1] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Biomed Res Ctr, Parque Tecnol Salud,Ave Conocimiento S-N, Granada 18100, Spain

[2] Estn Expt Zaidin CSIC, Dept Biochem, Cell & Mol Biol Plants, Prof Albareda 1, Granada 18008, Spain

[3] Fdn Publ Andaluza Invest Biosanitaria Andalucia O, Ave Madrid 15, Granada 18012, Spain

[4] CSIC, Inst Grasa, Food Phytochem Dept, Univ Campus Pablo de Olavide, Seville 41013, Spain

[5] ICSA, Ave Hispanidad 17, Granada 18320, Spain

[6] Univ Granada, Dept Med, Ave Invest 11, E-18071 Granada, Spain

[7] Hosp del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Dr Aiguader 88, Barcelona 08003, Spain

[8] Univ Pompeu Fabra CEXS UPF, Hosp del Mar Med Res Inst IMIM, Integrat Pharmacol & Syst Neurosci Res Grp, Dr Aiguader 88, Barcelona 08003, Spain

[9] Inst Salud Carlos III, Spanish Biomed Res Networking Ctr, Physiopathol Obes & Nutr CIBEROBN, Monforte de Lemos 3-5, Madrid 28029, Spain

[10] NUPROAS Handelsbolag, Nacka, Sweden

[11] NUPROAS HB, Apartado Correos 93, Girona 17242, Spain

[12] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Physiol, Parque Tecnol Salud,Ave Conocimiento S-N, Granada 18100, Spain

来源：

NUTRIENTS | 2018年 / 10卷 / 05期

关键词：

olive oil; virgin olive oil; olive oil polyphenols; maslinic acid; oleanolic acid; cardiovascular diseases; endothelial function; phenolic compounds; triterpenes; metabolic syndrome; MEDITERRANEAN DIETS; CARDIOVASCULAR RISK; PHENOLIC-COMPOUNDS; OLEANOLIC ACID; NITRIC-OXIDE; POLYPHENOLS; ATHEROSCLEROSIS; DYSFUNCTION; TRITERPENES; MECHANISMS;

D O I：

10.3390/nu10050626

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).

引用

页数：17

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