Vascular frontiers without borders: Multifaceted roles of platelet-derived growth factor (PDGF) in supporting postnatal angiogenesis and lymphangiogenesis

被引：28

作者：

Vincent, L ^{[1
]}

Rafii, S ^{[1
]}

机构：

[1] Cornell Univ, Coll Med, Dept Med Genet, Div Hematol Oncol, New York, NY 10021 USA

来源：

CANCER CELL | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2004.09.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The platelet-derived growth factor (PDGF) family of growth factors, which primarily serves the function of stabilizing vascular networks, has now been shown to play a role in promoting tumor lymphangiogenesis. PDGF-BB, independent of VEGFR-3 signaling, induces tumor growth and metastasis in part through supporting lymphangiogenesis. These data suggest that targeting the PDGF/PDGF-receptor signaling pathway will provide a novel strategy to block tumor neoangiogenesis and lymphangiogenesis, thereby inhibiting tumor growth and metastasis.

引用

页码：307 / 309

页数：3

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