A theranostic Mn-based metal-organic framework for T1-weighted magnetic resonance property and chemodynamic therapy

被引：13

作者：

Yu, Shijiang ^{[1
]}

Lin, Wenxin ^{[1
,2
]}

Huang, Xiajuan ^{[1
]}

Jin, Xiaokang ^{[1
]}

Yao, Shuting ^{[1
]}

Wang, Bing ^{[1
]}

Zhu, Hongliang ^{[1
]}

Chen, Jianjun ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Hangzhou 310018, Peoples R China

[2] Zhejiang Univ, Sch Mat Sci & Engn, State Key Lab Silicon Mat, Hangzhou 310027, Peoples R China

来源：

POLYHEDRON | 2021年 / 205卷

基金：

中国国家自然科学基金;

关键词：

Metal-organic frameworks; Fenton-like reaction; Chemodynamic therapy; T1-weighted magnetic resonance property; Divalent manganese ion;

D O I：

10.1016/j.poly.2021.115278

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A Mn-based metal-organic framework Mn-DA was synthesized from MnCl2 and organic azo ligand H(4)DA, and it was characterized by single crystal X-ray diffraction analysis, PXRD, FT-IR and TGA. The materials containing Mn2+ displayed magnetic resonance property and the ability of chemodynamic therapy. Then Mn2+ was selected and loaded into Mn-DA, which was called Mn@Mn-DA, to further improve the theranostic properties. Comparing with Mn-DA, Mn@Mn-DA exhibited more than twice of the relaxation rate and better chemodynamic therapy effect. Mn-based metal-organic framework Mn-DA showed ideal T1-weighted magnetic resonance property and chemodynamic therapy. In addition, the successful fabrication of Mn@Mn-DA provided a simple strategy to construct more effective systems for theranostic application. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：6

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