Rearrangements involving 12q in myeloproliferative disorders:: possible role of HMGA2 and SOCS2 genes

被引：26
作者：
Etienne, Anne
Carbuccia, Nadine
Adelaide, Jose
Bekhouche, Ismahane
Remy, Virginie
Sohn, Claudine
Sainty, Danielle
Gastaut, Jean-Albert
Olschwang, Sylviane
Birnbaum, Daniel
Mozziconacci, Marie-Joelle [1 ]
Chaffanet, Max
机构：
[1] Inst J Paoli I Calmettes, INSERM, UMR599, Ctr Rech & Cancerol,Lab Oncol Mol, F-13009 Marseille, France
[2] Hop Font Pre, Serv Oncol Hematol, F-83056 Toulon, France
[3] Inst J Paoli I Calmettes, Dept Biopathol, F-13009 Marseille, France
[4] Inst J Paoli I Calmettes, Dept Clin Hematol, F-13009 Marseille, France
来源：
CANCER GENETICS AND CYTOGENETICS | 2007年 / 176卷 / 01期
关键词：
D O I：
10.1016/j.cancergencyto.2007.03.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report two cases of translocation associated with deletion on derivative chromosomes in atypical myeloproliferative disorder (MPD). In a MPD with t(3;12)(q29;q14), the rearrangement targeted the HMGA2 locus at 12q14 and deleted a region of about 1.5 megabases (Mb) at 3q29. In an MPD with t(9;12)(q13 similar to q21;q22) and JAK2 V617F mutation, array comparative genomic hybridization delineated a deletion of about 3 Mb at 9q13 similar to q21 and a deletion of about 2 Mb at 12q22 containing SOCS2. These results show that close examination of translocations in hematopoietic diseases may reveal associated microdeletions. The role of these deletions is discussed. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：80 / 88
页数：9
相关论文
共 32 条
[1]   Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia [J].
Andrieux, J ;
Demory, JL ;
Dupriez, B ;
Quief, S ;
Plantier, I ;
Roumier, C ;
Bauters, F ;
Laï, JL ;
Kerckaert, JP .
GENES CHROMOSOMES & CANCER, 2004, 39 (01) :82-87
[2]   Frequency of structural abnormalities of the long arm of chromosome 12 in myelofibrosis with myeloid metaplasia [J].
Andrieux, J ;
Demory, JL ;
Morel, P ;
Plantier, I ;
Dupriez, B ;
Caulier, MT ;
Bauters, F ;
Lai, JL .
CANCER GENETICS AND CYTOGENETICS, 2002, 137 (01) :68-71
[3]   Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA [J].
Barrett, MT ;
Scheffer, A ;
Ben-Dor, A ;
Sampas, N ;
Lipson, D ;
Kincaid, R ;
Tsang, P ;
Curry, B ;
Baird, K ;
Meltzer, PS ;
Yakhini, Z ;
Bruhn, L ;
Laderman, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (51) :17765-17770
[4]   Signal transducer and activator of transcription proteins in leukemias [J].
Benekli, M ;
Baer, MR ;
Baumann, H ;
Wetzler, M .
BLOOD, 2003, 101 (08) :2940-2954
[5]   Large scale copy number variation (CNV) at 14q12 is associated with the presence of genomic abnormalities in neoplasia [J].
Braude, Ilan ;
Vukovic, Bisera ;
Prasad, Mona ;
Marrano, Paula ;
Turley, Stefanie ;
Barber, Dwayne ;
Zielenska, Maria ;
Squire, Jeremy A. .
BMC GENOMICS, 2006, 7 (1)
[6]   The tumor-associated gene HMGIC is expressed in normal and osteoarthritis-affected synovia [J].
Broberg, K ;
Tallini, G ;
Höglund, M ;
Lindstrand, A ;
Toksvig-Larsen, S ;
Mertens, F .
MODERN PATHOLOGY, 2001, 14 (04) :311-317
[7]   Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome [J].
Delaval, B ;
Létard, S ;
Lelièvre, H ;
Chevrier, V ;
Daviet, L ;
Dubreuil, P ;
Birnbaum, D .
CANCER RESEARCH, 2005, 65 (16) :7231-7240
[8]   Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder [J].
Etienne, Anne ;
Gelsi-Boyer, Veronique ;
Carbuccia, Nadine ;
Adelaide, Jose ;
Barba, Gianluca ;
La Starza, Roberta ;
Murati, Anne ;
Eclache, Virginie ;
Birg, Francoise ;
Birnbaum, Daniel ;
Mozziconacci, Marie-Joelle ;
Mecucci, Cristina ;
Chaffanet, Max .
CANCER GENETICS AND CYTOGENETICS, 2007, 173 (02) :154-158
[9]  
Fourouclas N, 2006, HAEMATOL-HEMATOL J, V91, P952
[10]  
Gattas GJF, 1999, GENE CHROMOSOME CANC, V25, P316, DOI 10.1002/(SICI)1098-2264(199908)25:4<316::AID-GCC2>3.3.CO
1234