A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury

被引：61

作者：

Lau, HY ^{[1
]}

Wong, FL ^{[1
]}

Bhatia, M ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 327卷 / 02期

关键词：

acute pancreatitis; substance P; CP-96345; caerulein;

D O I：

10.1016/j.bbrc.2004.12.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Earlier studies have shown that mice deficient in NK1 receptors or its ligand. substance R are protected against acute pancreatitis and associated lung injury. In the current study, the protective effect of NK1 receptor blockage against acute pancreatitis and associated lung injury was investigated, using a specific receptor antagonist, CP-96345. Acute pancreatitis was induced in mice by intraperitoneal (i.p.) injections of caerulein. Substance P levels in plasma, pancreas, and lungs were found to be elevated in a caerulein dose-dependent manner. Mice treated with CP-96345, either prophylactically, or therapeutically, were protected against acute pancreatitis and associated lung injury as evident by attenuation in plasma amylase, pancreatic and pulmonary myeloperoxidase activities, and histological evidence of pancreatic and pulmonary injuries. Pulmonary microvascular permeability was also reduced as a result of CP-96345 treatment. These results point to a key role of NK1 receptors in acute pancreatitis and associated lung injury. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：509 / 515

页数：7

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