Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

被引：7
作者：
Wong, Carmen P. [1 ]
Iwaniec, Urszula T. [1 ,2 ]
Turner, Russell T. [1 ,2 ]
机构：
[1] Oregon State Univ, Skeletal Biol Lab, Sch Biol & Populat Hlth Sci, Corvallis, OR 97331 USA
[2] Oregon State Univ, Ctr Hlth Aging Res, Corvallis, OR 97331 USA
来源：
NPJ MICROGRAVITY | 2021年 / 7卷 / 01期
关键词：
MOUSE; TORPOR; MODEL;
D O I：
10.1038/s41526-021-00150-y
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and beta-oxidation.
引用
收藏
页数：4
相关论文
共 27 条
  • [1] ADAPTATION OF MICE TO COLD
    BARNETT, SA
    [J]. BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY, 1965, 40 (01): : 5 - &
  • [2] TIME COURSE OF PERIPHERAL HETEROTHERMY IN A HOMEOTHERM
    BROWN, RT
    BAUST, JG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 239 (01): : R126 - R129
  • [3] Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation
    Choi, Sungshin Y.
    Saravia-Butler, Amanda
    Shirazi-Fard, Yasaman
    Leveson-Gower, Dennis
    Stodieck, Louis S.
    Cadena, Samuel M.
    Beegle, Janet
    Solis, Stephanie
    Ronca, April
    Globus, Ruth K.
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [4] Central control of thermogenesis
    Clapham, John C.
    [J]. NEUROPHARMACOLOGY, 2012, 63 (01) : 111 - 123
  • [5] Collins Sheila, 2011, Front Endocrinol (Lausanne), V2, P102, DOI 10.3389/fendo.2011.00102
  • [6] Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study
    Fischer, Alexander W.
    Cannon, Barbara
    Nedergaard, Jan
    [J]. MOLECULAR METABOLISM, 2018, 7 : 161 - 170
  • [7] Fleige Simone, 2006, Molecular Aspects of Medicine, V27, P126, DOI 10.1016/j.mam.2005.12.003
  • [8] Warming the mouse to model human diseases
    Ganeshan, Kirthana
    Chawla, Ajay
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2017, 13 (08) : 458 - 465
  • [9] Torpor in mice is induced by both leptin-dependent and -independent mechanisms
    Gavrilova, O
    Leon, LR
    Marcus-Samuels, B
    Mason, MM
    Castle, AL
    Refetoff, S
    Vinson, C
    Reitman, ML
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (25) : 14623 - 14628
  • [10] Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold
    Golozoubova, V
    Hohtola, E
    Matthias, A
    Jacobsson, A
    Cannon, B
    Nedergaard, J
    [J]. FASEB JOURNAL, 2001, 15 (09) : 2048 - +
123