Generation of an induced pluripotent stem cell line SDQLCHi026-A from a hereditary tyrosinemia type I patient carrying compound heterozygote mutations in FAH gene

被引：1

作者：

Zhang, Haiyan ^{[1
]}

Liu, Chen ^{[2
]}

Ma, Yanyan ^{[1
]}

Lin, Lin ^{[2
]}

Lv, Yuqiang ^{[1
]}

Gao, Min ^{[1
]}

Gai, Zhongtao ^{[1
]}

Liu, Yi ^{[1
]}

机构：

[1] Shandong Univ, Pediat Res Inst, Qilu Childrens Hosp, Cheeloo Coll Med, Jinan 250022, Shandong, Peoples R China

[2] Shandong Univ, Qilu Childrens Hosp, Neonatal Dept, Cheeloo Coll Med, Jinan 250022, Shandong, Peoples R China

来源：

STEM CELL RESEARCH | 2021年 / 53卷

基金：

中国国家自然科学基金;

关键词：

iPSC; Reprogramming; hereditary tyrosinemia type I; FAH;

D O I：

10.1016/j.scr.2021.102331

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient diagnosed as hereditary tyrosinemia type I (HT1) caused by FAH gene mutation. Induced pluripotent stem cells (iPSCs) were developed using non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and MYC. The established iPSC line (SDQLCHi026-A) displayed pluripotent cell morphology, high expression levels of pluripotency markers, differentiation potential in vitro, normal karyotype, and remaining the original FAH gene mutation.

引用

页数：4