Plasminogen Activator Inhibitor-1 4G/5G Promoter Polymorphism in Adults with Splanchnic Vein Thrombosis: A Case-Control Study

被引：5

作者：

Kollabathula, Arpitha ^{[1
]}

Sharma, Saniya ^{[2
]}

Kumar, Narender ^{[2
]}

Ahluwalia, Jasmina ^{[2
]}

Das, Reena ^{[2
]}

Varma, Neelam ^{[2
]}

Rana, Surinder Singh ^{[3
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Pathol, Sect 12, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Dept Hematol, Level 5,Res Block A,Sect 12, Chandigarh 160012, India

[3] Postgrad Inst Med Educ & Res, Dept Gastroenterol, Sect 12, Chandigarh 160012, India

来源：

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | 2022年 / 38卷 / 01期

关键词：

Amplification refractory mutation system; Plasminogen activator inhibitor-1; PAI-1; 4G; 5G polymorphism; Splanchnic vein thrombosis; Thrombophilia; RISK-FACTORS; PAI-1; GENE; MTHFR; 677TT; V-LEIDEN; 4G-4G;

D O I：

10.1007/s12288-021-01454-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of PAI-1 4G/5G polymorphism in venous thrombosis is unclear. PAI-1 4G/4G genotype is associated with elevated levels of PAI-1 resulting in a hypofibrinolytic state and hence increased thrombotic risk. In this study, we assessed the role of PAI-1 4G/5G promoter polymorphism in adult patients with splanchnic vein thrombosis. A total of 40 cases (portal vein thrombosis and Budd-Chiari syndrome) and 40 healthy controls were evaluated for the PAI-14G/5G polymorphism by amplification refractory mutation system polymerase chain reaction along with thrombophilia workup. The frequency of PAI-1 4G/4G homozygous, 4G/5G heterozygous and 5G/5G homozygous genotypes were 17.5%, 42.5% and 40%, respectively among cases and 22.5%, 50% and 27.5%, respectively among controls and the difference was not statistically significant (p = 0.61). The PAI-1 4G/4G genotype was significantly associated with the cases with deranged thrombophilic risk factor (both inherited and acquired) (p = 0.02).

引用

页码：169 / 172

页数：4

共 12 条

[1] Plasminogen Activator Inhibitor-1 (PAI-1) Gene 4G/5G Promoter Polymorphism is Seen in Higher Frequency in the Indian Patients With Deep Vein Thrombosis [J].

Akhter, Mohammed Suhail ;

Biswas, Arijit ;

Ranjan, Ravi ;

Meena, Arvind ;

Yadav, Birendra Kumar ;

Sharma, Amit ;

Saxena, Renu .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2010, 16 (02) :184-188

[2] Inherited and Acquired Risk Factors for Venous Thromboembolism [J].

Baglin, Trevor .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 33 (02) :127-137

[3] PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs [J].

Balta, G ;

Altay, C ;

Gurgey, A .

AMERICAN JOURNAL OF HEMATOLOGY, 2002, 71 (02) :89-93

[4] Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population [J].

D'Amico, Mario ;

Pasta, Francesca ;

Pasta, Linda .

GENE, 2015, 568 (01) :85-88

[5] Risk factors of thrombosis in abdominal veins [J].

Dutta, Amit Kumar ;

Chacko, Ashok ;

George, Biju ;

Joseph, Joseph Anjilivelil ;

Nair, Sukesh Chandran ;

Mathews, Vikram .

WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (28) :4518-4522

[6]

Francis CW, 2002, ARCH PATHOL LAB MED, V126, P1401

[7] PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three Prospective Studies [J].

Pasta, Linda ;

Pasta, Francesca ;

D'Amico, Mario .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2016, 6 (01) :10-14

[8] Investigation of Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G promoter polymorphism in Indian venous thrombosis patients: A case-control study [J].

Prabhudesai, Aniket ;

Shetty, Shrimati ;

Ghosh, Kanjaksha ;

Kulkarni, Bipin .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2017, 99 (03) :249-254

[9] Clinical approach to splanchnic vein thrombosis: Risk factors and treatment [J].

Riva, Nicoletta ;

Donadini, Marco P. ;

Dentali, Francesco ;

Squizzato, Alessandro ;

Ageno, Walter .

THROMBOSIS RESEARCH, 2012, 130 :S1-S3

[10] The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia [J].

Sartori, MT ;

Danesin, C ;

Saggiorato, G ;

Tormene, D ;

Simioni, P ;

Spiezia, L ;

Patrassi, GM ;

Girolami, A .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2003, 9 (04) :299-307

← 1 2 →