Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics

被引：12

作者：

Cruz-Acuna, Ricardo ^{[1
,2
]}

Vunjak-Novakovic, Gordana ^{[3
]}

Burdick, Jason A. ^{[4
]}

Rustgi, Anil K. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Med, Div Digest & Liver Dis, Irving Med Ctr, New York, NY 10027 USA

[2] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Irving Med Ctr, New York, NY 10027 USA

[3] Columbia Univ, New York, NY USA

[4] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

ISCIENCE | 2021年 / 24卷 / 05期

关键词：

PANCREATIC DUCTAL ADENOCARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; GENERATION IMAGING MICROSCOPY; PHASE-III TRIAL; IN-VITRO MODEL; CLINICAL-SIGNIFICANCE; INCREASED EXPRESSION; TUMOR; COLLAGEN; METASTASIS;

D O I：

10.1016/j.isci.2021.102475

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent engineering technologies have transformed traditional perspectives of cancer to include the important role of the extracellular matrix (ECM) in recapitulating the malignant behaviors of cancer cells. Novel biomaterials and imaging technologies have advanced our understanding of the role of ECM density, structure, mechanics, and remodeling in tumor cell-ECMinteractions in cancer biology and have provided new approaches in the development of cancer therapeutics. Here, we review emerging technologies in cancer ECM biology and recent advances in engineered systems for evaluating cancer therapeutics and provide new perspectives on howengineering tools present an opportunity for advancing themodeling and treatment of cancer. This review offers the cell biology and cancer cell biology communities insight into how engineering tools can improve our understanding of cancer ECM biology and therapeutic development.

引用

页数：18

共 139 条

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